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TranscriptomicsAntitumor Activity of (R,R’)-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse
(R,R’)-4-methoxy-1-naphthylfenoterol (MNF) inhibits in vitro proliferation of several types of cancer cell lines. In this study, the in vivo antitumor effects of MNF were evaluated using rat C6 glioma cells implanted subcutaneously into the lower flank of 5 week-old NMRI/Nude female Swiss mice. Thre...
ORGANISM(S): Rattus norvegicus 
2015-08-06 | E-GEOD-45307 | biostudies-arrayexpress
GenomicsAscl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts [ChIP-seq]
Wnt signals control three functions of intestinal crypts: maintenance of Lgr5 stem cells, proliferation of transit-amplifying daughters and formation of Paneth cells. Here, we study how the Wnt effector β-catenin/Tcf4 cooperates with the Wnt-activated transcription factor Ascl2 to control a stem ce...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-84456 | biostudies-arrayexpress
TranscriptomicsMicroRNAs expression in 20(R)-ginsenoside Rg3-induced anti-angiogenesis
The angio-suppressive effect of 20(R)-ginsenoside Rg3 (Rg3-R) has been previously demonstrated, and microRNAs (miRNAs) are a vital group of small non-coding RNAs that function as post-transcriptional modulator of gene expression. Thus, using human umbilical vein endothelial cells (HUVEC) as model, w...
ORGANISM(S): Homo sapiens 
2011-09-09 | E-GEOD-31959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis with post-transcriptionally silenced Myosin XI-K
This study was aimed to determine roles of individual myosins in organelle trafficking in plant cell. Expression of Myosin XI-K was suppressed in transgenic A.thaliana by using RNAi approach. To ensure that the RNAi-induced gene silencing was specific and did not affect expression of other myosins,...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5431 | biostudies-arrayexpress
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
UnknownSoluble RAGE attenuates myocardial I/R injuries via FoxO3-Bnip3 pathway.
Not available
S-EPMC11072718 | biostudies-literature
UnknownA highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Not available
S-EPMC9309443 | biostudies-literature
UnknownGustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment.
Not available
S-EPMC12277832 | biostudies-literature
Genomics
RNA-seq of primary astrocytes following rMS intervention in an OGD/R model
PRJNA1490330 | ENA
UnknownCreating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.
Not available
S-EPMC4309560 | biostudies-literature
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