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TranscriptomicsHigh-resolution chromosomal maps of Xist RNA reveal a two-step spreading mechanism during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X (Xi) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation center (Xic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-48649 | biostudies-arrayexpress
TranscriptomicsIdentification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here, we sought to prospectively identify chemicals that share transcriptomic signatures with neurological disorders by exposing mouse cortical neuron-enri...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-70249 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human angiomyolipoma xenograft tumours grown in mice after estrogen treatment
SV7tert AML cells were obtained from ATCC and cultured in Dulbecco's modified essential medium (DMEM), glutamine (4mmol) and 10% foetal bovine serum (FBS). Two million SV7tertAML cells were subcutaneously injected into nude mice either with or without subcutaneous oestrogen pellets (n=4 per group);...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5868 | biostudies-arrayexpress
TranscriptomicsSAGE tags generated from Triticum aestivum cultivars Scorpion 25 and Xi19 grown under normal and hot/dry conditions
Triticum aestivum cultivars Scorpion 25 and Xi 19 were grown under both normal and hot/dry conditions. We compared the effect of these two growth conditions on these two closely related varieties. We sequenced two biological replicates each for both Scorpion 25 and Xi19 grown under normal conditio...
ORGANISM(S): Triticum aestivum 
2008-09-20 | E-GEOD-12832 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary bone marrow derived mouse macrophages M-bM-^@M-^S untreated and treated with LPS or LPS+PGE
The polarization of macrophages into an anti-inflammatory or regulatory phenotype plays an important role in resolving inflammation. PGE2 regulates macrophage polarization via a PKA dependent pathway. PKA phosphorylates SIKs, inhibiting their ability to phosphorylate CRTC3 in cells. This in turn ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-41833 | biostudies-arrayexpress
ProteomicsA high confidence Physcomitrium patens plasmodesmata proteome
Cells of multicellular organisms exchange nutrients, building blocks and information. In animals this exchange happens via gap junctions, in plants via plasmodesmata (PD). PD have striking properties with a large range of molecules from ions, to metabolites and synthetic dyes, RNA and proteins up t...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) 
2024-01-18 | PXD032820 | Pride
Plasmodesmata Physcomitrium patens Proteome 
TranscriptomicsHuman TNBC Cells 48h Treatment with OTSSP167 MELK Inhibitor vs. DMSO Control
Microarray comparing TNBC cells treated for 48 hours with OTSSp167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 48h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68652 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 45nM OTSSP167 MELK Inhibitor vs. DMSO Control
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 45nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68692 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 4.5nM OTSSP167 MELK Inhibitor vs. DMSO Control
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: MDA-MB-231 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-68691 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 4.5nM OTSSP167 MELK Inhibitor vs. DMSO Control (SUM159)
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: SUM159 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-71026 | biostudies-arrayexpress
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