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TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
GenomicsXi Zang
Xi Zang Raw sequence reads
PRJNA1440896 | ENA
GenomicsSpreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichm...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36905 | biostudies-arrayexpress
TranscriptomicsHigh-resolution chromosomal maps of Xist RNA reveal a two-step spreading mechanism during X-inactivation
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X (Xi) and recruits Polycomb Repressive Complex 2 (PRC2) to the X-inactivation center (Xic...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-48649 | biostudies-arrayexpress
GenomicsMetagenome raw data (IX,X,XI) corrected for different pollutants
Metagenome raw data (IX,X,XI) corrected for different pollutants Raw sequence reads
PRJNA996291 | ENA
GenomicsSite-specific silencing of regulatory elements as a mechanism of X-inactivation
The inactive X chromosome’s (Xi) physical territory is microscopically devoid of transcriptional hallmarks and enriched in silencing-associated modifications. How these microscopic signatures relate to specific Xi sequence is unknown. This study reports the profiling of Xi gene expression and chroma...
ORGANISM(S): Mus musculus 
2012-11-21 | E-GEOD-39406 | biostudies-arrayexpress
GenomicsSmchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
X chromosome inactivation involves multiple levels of chromatin modification, established progressively and in a stepwise manner during early development. The chromosomal protein Smchd1 has recently been shown to play an important role in DNA methylation of CpG islands (CGIs), a late step in the X i...
ORGANISM(S): Mus musculus 
2012-10-15 | E-GEOD-37333 | biostudies-arrayexpress
GenomicsXist RNA regulates remodeling of the Xi during B cell stimulation [RNA-seq]
Xist RNA regulates remodeling of the Xi during B cell stimulation [RNA-seq]
PRJNA859802 | ENA
GenomicsXist RNA regulates remodeling of the Xi during B cell stimulation [Hi-C]
Xist RNA regulates remodeling of the Xi during B cell stimulation [Hi-C]
PRJNA874717 | ENA
TranscriptomicsRNA Seq analysis of Mefs Isolated from STC1+/+ and STC1-/- mice
Evaluation of X-linked gene expression in MEFs isolated from STC1 wild type and knock out mice X chromosome inactivation (XCI) is initiated in cis by the Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. We performed a large-scale RNA interference screen to identify tr...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-47395 | biostudies-arrayexpress
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