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GenomicsChromatin enrichment of TRIM24, estrogen receptor and H3K4me2 in estrogen-treated and -untreated MCF7 cells
TRIM24 PHD-Bromo domains exhibit preferential binding to unmethylated H3K4 and acetylated H3K27. TRIM24 is a co-activator of estrogen receptor (ER). The results suggest that specific ER-binding sites are depleted of H3K4me2 with estrogen treatment. TRIM24 binds these sites preferentially and faci...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-24166 | biostudies-arrayexpress
UnknownCardiac disease modeling using induced pluripotent stem cell-derived human cardiomyocytes.
Not available
S-EPMC4369490 | biostudies-literature
UnknownER-GCaMP6f: An Endoplasmic Reticulum-Targeted Genetic Probe to Measure Calcium Activity in Astrocytic Processes.
Not available
S-EPMC9047445 | biostudies-literature
TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
UnknownRole of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis.
Not available
S-EPMC11807764 | biostudies-literature
TranscriptomicsRNA sequencing of endocrine resistant breast cancer
*** This submission includes RNA data, with DNA files available under a different accession number*** Purpose: Endocrine therapy resistance remains the greatest challenge for treating hormone receptor positive breast cancer patients. We aim to identify molecular mechanisms underlying endocrine ther...
ORGANISM(S): Homo sapiens 
2022-09-01 | E-MTAB-9917 | biostudies-arrayexpress
UnknownUterine Injury Caused by Genotype 4 Hepatitis E Virus Infection Based on a BALB/c Mice Model.
Not available
S-EPMC8538062 | biostudies-literature
UnknownCrystal growth engineering and origin of the weak ferromagnetism in antiferromagnetic matrix of orthochromates from t-e orbital hybridization.
Not available
S-EPMC8983379 | biostudies-literature
Transcriptomicshuman leukemia cell line K562 offspring acquring imatinib resistance(K562-r) : Control vs. Drug treated
Transcriptional profiling of K562-r comparing control untreated human leukemia cells with human leukemia cells treated with AMN107 and ATO individually or combined.Four timepoints included are 3h,12h,24h,48h, covering the whole time window of K562-r cells responsing to the drug treatment.At the comb...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-24946 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonal rhabdomyosarcoma (EMRS) culture to identify PAX3-FKHR regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcomas
The overall goal and objective is to study the degree to which PAX3-FKHR accounts for differences between ARMS and ERMS by expressing a construct (termed P3FK/ER) consisting of PAX3-FKHR joined to the estrogen receptor ligand binding domain in an ERMS cell culture system. Experiment Overall Design: ...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-GEOD-15103 | biostudies-arrayexpress
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