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MetabolomicsComparative analysis of proteomic and metabolomic profiles of different species of Paris

An extract prepared from species of Paris is the most widely consumed herbal product in China. The genus Paris includes a variety of genotypes with different medicinal component contents but only two are defined as official sources. Closely related species have different medicinal properties beca...

2020-01-13 | MTBLS779 | MetaboLights
ProteomicsOMe-Ph-Elemene treated colorectal cancer cells for proteomics sequencing
The novel elemene derivative, OMe-Ph-Elemene, attenuates oxidative phosphorylation and facilitates apoptosis by inducing intracellular reactive oxygen species
ORGANISM(S): Homo Sapiens 
PXD055327 |
TranscriptomicsGene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
ProteomicsTalaroconvolutin-A treated bladder cancer for proteomics sequencing
TalaA inhibits bladder cancer mainly through two approaches: 1) arresting cell cycle to suppress proliferation, 2) triggering ferroptosis to cause cell death. In molecular mechanism, TalaA can interact with MAPKs to repress the phosphorylation of transcription regulators. This study would open new a...
ORGANISM(S): Homo Sapiens 
PXD037785 |
ProteomicsMegavirus Translation Initiation Factor 4A Plays an Important Role in the Regulation of Viral and Host Protein Translation and Host Adaptation
The presence of translation-related proteins has long been seen as a critical distinction between viruses and cellular life, the discovery of giant viruses has challenged this standard. We prove that the potential eukaryotic translation initiation factor 4A (eIF4A, Mb0671) encoded by the Megavirus b...
ORGANISM(S): Mimivirus Sp. Sh 
PXD056594 |
UnknownA New Criterion for Pediatric AKI Based on the Reference Change Value of Serum Creatinine.
Not available
S-EPMC6115652 | biostudies-literature
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