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MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
UnknownStrategies of laparoscopic spleen-preserving splenic hilar lymph node dissection for advanced proximal gastric cancer.
Not available
S-EPMC4919707 | biostudies-literature
ProteomicsTargeting G9a Regulated m6A Modification Pathway to Hinder SARS-CoV-2 Replication
N6-methyladenosine (m6A) modification pathway is hijacked by several RNA viruses, including SARS-CoV-2, making it an attractive host-directed target for development of broad-spectrum antivirals. Here, we show that histone methyltransferase G9a, through its interaction with METTL3, regulates SARS-CoV...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD058743 | Pride
Covid-19 Sars-cov-2 
ProteomicsNovel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication
we developed a novel brain-penetrant inhibitor of G9a, MS1262, across the blood-brain barrier to block this G9a-regulated, proteopathologic mechanism. Intermittent MS1262 treatment of multiple AD mouse models consistently restored both cognitive and noncognitive functions to healthy levels. Comparis...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD047045 | Pride
Lc-ms Alzheimer’s 
UnknownA Multi-Method Approach to Analyzing MOFs for Chemical Warfare Simulant Capture: Molecular Simulation, Machine Learning, and Molecular Fingerprints.
Not available
S-EPMC11820582 | biostudies-literature
UnknownNetwork-directed efficient isolation of previously uncultivated Chloroflexi and related bacteria in hot spring microbial mats.
Not available
S-EPMC7190741 | biostudies-literature
ProteomicsMass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress
A 2D-LC-MS/MS strategy coupled with TMT-10 labeling was applied to mouse pancreatic beta cells (hetaTC-6) induced with ER stress by Thapsigargin to study the global proteome and protein cysteine PTM changes under ER stress. Samples were digested with trypsin, labeled with 10-plex TMT, then analyzed ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-05-29 | MSV000087543 | MassIVE
TranscriptomicsGene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray
Osteoarthritis (OA) is a complex degenerative joint disease, which is not only a cartilage but also a bone disease. A better understanding of the early molecular mechanism changes of subchondral bone in vivo may contribute to elucidating the pathogenesis of OA. We used microarray technology to inves...
ORGANISM(S): Rattus norvegicus 
2012-12-11 | E-GEOD-30322 | biostudies-arrayexpress
Proteomics2H-Thiopyran-2-Thione Sulfine, a Compound For Converting H2S to HSOH/H2S2 and Increasing Intracellular Sulfane Sulfur Levels
Reactive sulfane sulfur species such as persulfides (RSSH) and H2S2 are important redox regulators and closely linked to H2S signaling. However, the study of these species is still challenging due to their instability, high reactivity, and the lack of suitable donors to produce these species. Herein...
ORGANISM(S): Oryctolagus Cuniculus (ncbitaxon:9986) 
2024-02-07 | MSV000094034 | MassIVE
UnknownHigh-quality draft genome sequence of the Thermus amyloliquefaciens type strain YIM 77409(T) with an incomplete denitrification pathway.
Not available
S-EPMC4769583 | biostudies-literature
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