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MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
UnknownXiao-Chai-Hu Decoction Ameliorates Poly (I:C)-Induced Viral Pneumonia through Inhibiting Inflammatory Response and Modulating Serum Metabolism.
Not available
S-EPMC9296287 | biostudies-literature
TranscriptomicsCryptic Transcription in a set2∆ in Saccharomyces cerevisiae
In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-17 | E-GEOD-13310 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Procr-expressing mouse mammary myoepithelium
Procr, also known as EPCR, is a protein C receptor known to function in the platelet coagulation cascade. We have used RNA-seq to examine RNA differential expression between Procr+ and Procr- myoepithelium in mouse mammary gland. Examine RNA differential expression among subsets of freshly sorted mo...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-58088 | biostudies-arrayexpress
ProteomicsThe proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in glioblastoma and remodel...
ORGANISM(S): Homo sapiens (Human) 
2024-07-29 | PXD054314 | Pride
Acss2 Fatty acid synthesis Acly 
MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
ProteomicsGu-Ben-Fang-Xiao decoction ameliorates airway remodeling by regulating the PI3K/AKT signaling pathway mediated by RTN4 in a chronic remission asthma murine model
Airway remodeling is a main pathological feature of asthma. The current therapy for asthma is mainly targeted for reducing inflammation, not particularly for airway remodeling. Herein, developing alternative and more effective therapy to attenuate remodeling is worthy of further study. Gu-Ben-Fang-X...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020711 | Pride
Rtn4 Pi3k/akt pathway Gu-ben-fang-xiao decoction Chronic remission asthma Airway remodeling 
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of aged (Day10) and young (L4) C. elegans Transcriptomes
Next Generation Sequencing Facilitates Quantitative Analysis of aged (Day10) and young (L4) C. elegans Transcriptomes
PRJNA734866 | ENA
ProteomicsProteome of UFD-2 in C. elegans
Proteome of UFD-2 in C. elegans, which is expressed under the heat shock promoter.
ORGANISM(S): Caenorhabditis Elegans 
2026-09-28 | PXD084870 |
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