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UnknownFu Zheng Xiao Yu San Jie Decoction affects the proliferation of renal cell carcinoma via regulating <i>E2F5</i> gene.

Background

Renal cell carcinoma (RCC) is a prevalent disease within the urinary system, characterized by high mortality rates. Its incidence is increasing each year, posing a significant threat to public health. Currently, the causes of RCC are not fully understood, and there are many limita...
S-EPMC12779431 | biostudies-literature
UnknownTreatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach.
Berberine, baicalin, and jasminoidin were major active ingredients of Huang-Lian-Jie-Du-Decoction (HLJDD), a famous prescription of traditional Chinese medicine (TCM), which has been used for the treatment of ischemic stroke. The aim of the present study was to classify their roles in the treatment ...
S-EPMC5574319 | biostudies-literature
UnknownInhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1.
Huang-Lian-Jie-Du-Tang (HLJDT), a traditional formula with four TCM herbs, has been used for hundred years for different diseases. The current study aimed to assess the inhibitory activity of HLJDT against H1N1 neuraminidase (NA-1), and identify potent NA-1 inhibitors from its plasma profile. The in...
S-EPMC5686190 | biostudies-literature
MetabolomicsComparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study
Background: Autism spectrum disorder (ASD) is defined as a pervasive developmental disorder which is caused by genetic and environmental risk factors. Besides the core behavioral symptoms, accumulated results indicate children with ASD also share some metabolic abnormalities. Objectives:
2022-03-02 | MTBLS2421 | MetaboLights
UnknownSynergistic Use of Geniposide and Ginsenoside Rg1 Balance Microglial TNF-α and TGF-β1 following Oxygen-Glucose Deprivation In Vitro: A Genome-Wide Survey.
Ischemia-activated microglia are like a double-edged sword, characterized by both neurotoxic and neuroprotective effects. The aim of this study was to reveal the synergistic effect of geniposide and ginsenoside Rg1 based on tumor necrosis factor- (TNF-) α and transforming growth factor- (TGF-) β1 ba...
S-EPMC4677035 | biostudies-literature
UnknownInflammatory microenvironment and expression of chemokines in hepatocellular carcinoma.

Aim

To study the inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma (HCC) in nude mice.

Methods

CBRH-7919 HCC cells were injected into the subcutaneous region of nude mice. Beginning two weeks after the challenge, tumor growth was measured every wee...
S-EPMC4408458 | biostudies-literature
UnknownRisks of stroke and myocardial infarction after retinal artery occlusion and their time dependence: a systematic review and meta-analysis.

Background

Retinal artery occlusion (RAO) is an ophthalmic emergency that may signal underlying cardiovascular disease. Both stroke and myocardial infarction (MI) share pathophysiological mechanisms and risk factors with RAO. This systematic review aimed to assess the risks of stroke and MI ...
S-EPMC12537614 | biostudies-literature
UnknownPeripheral blood transcriptomic analysis identifies potential inflammation and immune signatures for central retinal artery occlusion.
Central retinal artery occlusion (CRAO) is an acute retinal ischaemic disease, but early diagnosis is challenging due to a lack of biomarkers. Blood samples were collected from CRAO patients and cataract patients. Gene expression profiles were distinct between arterial/venous CRAO blood (A-V group) ...
S-EPMC10978867 | biostudies-literature
UnknownAnti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma.

Background

POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome still has no standard treatment. On the basis that both POEMS syndrome and myeloma have an underlying plasma cell dyscrasia, anti-myeloma therapy can be expected to be useful for...
S-EPMC6198365 | biostudies-literature
UnknownFecal microbiota characteristics of Chinese patients with primary IgA nephropathy: a cross-sectional study.

Background

Growing evidence has shown that the gut-renal connection and gut microbiota dysbiosis play a critical role in immunoglobulin A nephropathy (IgAN). However, the fecal microbiome profile in Chinese patients with IgAN remains unknown. A cross-sectional study was designed for the firs...
S-EPMC7071635 | biostudies-literature
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