Sort   by:  
 Page size 
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
ProteomicsUrinary Proteomic of Myasthenia Gravis
We conducted data-independent acquisition (DIA) proteomic profiling using a high-resolution Orbitrap Astral mass spectrometer on urine samples from 10 MG patients and 10 healthy volunteers.
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072289 |
Proteomicsthe MS data involved in the article "Nuclear ACAT1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer"
In this study we aim to explore the metabolic enzyme that affects NK cell function in colorectal cancer, and mainly focus on the mechanism how nuclear ACAT1（Mitochondrial acetyl-CoA acetyltransferase）promotes NK cell infiltration and activation
ORGANISM(S): Homo Sapiens 
2025-03-18 | PXD061959 |
MetabolomicsSarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating ant-inflammatory macrophages (cohort1)

Age-related changes in circulating metabolites significantly influence systemic physiology and may contribute to diseases like sarcopenia. Although metabolic dysregulation is closely linked to sarcopenia, the roles of specific metabolites remain unclear. Here we performed comprehensive plasma met...

2025-05-06 | MTBLS12015 | MetaboLights
MetabolomicsSarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating ant-inflammatory macrophages (cohort2)

Age-related changes in circulating metabolites significantly influence systemic physiology and may contribute to diseases like sarcopenia. Although metabolic dysregulation is closely linked to sarcopenia, the roles of specific metabolites remain unclear. Here we performed comprehensive plasma met...

2025-05-06 | MTBLS12036 | MetaboLights
ProteomicsDecipering the molecular mechanism of ACE2 regulating A549 cells
In the current study, using a lentivirus-based expression system in lung cancer cells (A549), we show that ACE2 overexpression reduces the viability and migratory potential of cancer cells, highlighting the robust anti-tumorigenic effects of ACE2 function. Moreover, a quantitative proteome-level com...
ORGANISM(S): Homo Sapiens 
2021-03-22 | PXD024899 |
ProteomicsDegrading fungi in WAS fermentation via enriching a fungi-degrading consortium (FDC)
Macroproteomics data from WAS (FDC) and fungi. degrading fungi on WAS fermentation
ORGANISM(S): Candida Albicans 
2025-12-03 | PXD071625 |
ProteomicsThe plasma DIA proteomic analysis for humans aimming at exploring the mechanism of RIPC’s protective effect under hypobaric hypoxia condition.
The plasma proteome profiling data come from the humans who received remote ischemic preconditioning treatment and experienced hypobaric hypoxia exposure then.
ORGANISM(S): Homo Sapiens 
2022-01-25 | PXD031247 |
ProteomicsPPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To ma...
ORGANISM(S): Homo Sapiens 
2023-02-21 | PXD040301 |
ProteomicsProteomic analysis of chronic skin wounds in diabetic mice following electrical stimulation therapy delivered by a novel electrostimulation-hydrogel wound dressing
In this study, we established a type 2 diabetes model in C57BL/6 mice through high-fat diet induction and STZ injection. Based on this animal model, we simulated clinically common hard-to-heal chronic diabetic skin wounds by implanting a mixed bacterial fluid, including Methicillin-resistant Staphyl...
ORGANISM(S): Mus Musculus 
2023-08-29 | PXD044920 |
Sort   by:  
 Page size