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UnknownPlasticity of Ly-6C(hi) myeloid cells in T cell regulation.
Not available
S-EPMC3159773 | biostudies-literature
GenomicsMediator Complex Regulates Alternative mRNA Processing via the Med23 Subunit
Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its Med23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recomb...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-33887 | biostudies-arrayexpress
TranscriptomicsCell-type restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
Tumor metastasis remains the major cause of cancer-related death, but its molecular basis is still not well understood. Here we uncovered a splicing-mediated pathway that is essential for breast cancer metastasis. We show that the RNA-binding protein hnRNPM promotes breast cancer metastasis by activ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-57243 | biostudies-arrayexpress
TranscriptomicsMediator Complex Regulates Alternative mRNA Processing via the Med23 Subunit
Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its Med23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recomb...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-33771 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of gemcitabine sensitive BxPC-3 pancreatic cancer cell lines and their derived resistant subclones, Bx-GEM
This experiment describes the differential gene expression between parental gemcitabine-sensitive BxPC-3 cells and their resistant subclones, Bx-GEM. To select for the resistant subclones, parental BxPC-3 cells were treated with increasing concentrations of gemcitabine (10, 25, 50, 100 and 200 nM) f...
ORGANISM(S): Homo sapiens 
2017-01-20 | E-MTAB-4901 | biostudies-arrayexpress
Transcriptomicsidentification of TGCT genes involved in initiation and maintenance of transformed germ cells.
Initially, we had compared gene expression differences in the embryonic gonads (E13.5) of the 129 and M19 strains by performing microarray analysis. These studies allowed us to identify downregulation of expression of the D19Bwg1357e, Zfp162 and Cox15 genes in the M19 strain. We next decided to exa...
ORGANISM(S): Mus musculus 
2009-12-30 | E-GEOD-14481 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-14354 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling by array of gemcitabine sensitive BxPC-3 pancreatic cancer cell lines and their derived resistant subclones, Bx-GEM
This experiment describes the differential microRNA expression between parental gemcitabine-sensitive BxPC-3 cells and their resistant subclones, Bx-GEM. To select for the resistant subclones, parental BxPC-3 cells were treated with increasing concentrations of gemcitabine (10, 25, 50, 100 and 200 n...
ORGANISM(S): Homo sapiens 
2017-01-20 | E-MTAB-4927 | biostudies-arrayexpress
UnknownActin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition.
Not available
S-EPMC4834727 | biostudies-literature
Proteomicshuman salivary extracellulae vesicles LC-MS/MS
using a facile method to prepare human salivary extracellular vesicles, and using LC-MS/MS to analysis the salivary extracellular vesicles proteomic. then we compared the healty donors with the lung cancer to discover potential biomarker.
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003269 | Pride
Human  saliva  vesicles  lc-ms/ms 
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