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Cathepsin D is reportedly to be closely associated with tumor development, migration and invasion, but its pathological mechanism is not fully elucidated. We aimed to evaluate phenotypic changes and molecular events in response to cathepsin D knockdown. Lowering endogenous cathepsin D abundance (CR)...
ORGANISM(S): Homo sapiens (Human) 
2015-12-17 | PXD002844 | Pride
Our study is highly relevant to the fields of Medical Bioinformatics and Personalised Medicine, as it employs high-throughput omics technologies and bioinformatics analyses to uncover personalized biomarkers predictive of treatment response, thereby paving the way for tailored therapeutic strategi...
ORGANISM(S): Homo Sapiens 
2026-02-02 | PXD073923 |
As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characteriz...
ORGANISM(S): Homo Sapiens 
2022-07-14 | PXD035365 |
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