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ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
TranscriptomicsMiRNA-127 Inhibits IgG Immune Complex-induced Lung Inflammation by Targeting IgG Fcγ Receptor I
The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs (miRNAs) are crucial biological regulators that act by suppressing their target genes and are involved in a variety of pathophysiologic processes. MiR-127 appeared to be down-regulated during lung injury. We set out...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-27642 | biostudies-arrayexpress
ProteomicsCell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators
Li J, Han S, Li H, Udeshi ND, Svinkina T, Mani DR, Xu C, Guajardo R, Xie Q, Li T, Luginbuhl DJ, Wu B, McLaughlin CN, Xie A, Kaewsapsak P, Quake sR, Carr SA, Ting AY, Luo L. 2019. Molecular interactions at the cellular interface mediate organized assembly of single cells into tissues, and thus govern...
ORGANISM(S): Drosophila <fruit Fly, Genus> (ncbitaxon:7215) 
2019-11-06 | MSV000084543 | MassIVE
ProteomicsTranscription Factor Acj6 Specifies Distinct Dendrite Targets via Unique Cell-Surface Protein Combinations
Xie Q, Li J1, Li H, Udeshi ND, Svinkina T, Kohani S, Guajardo R, Mani DR, Xu C, Li T, Han S, Wei W, Shuster SA, Luginbuhl DJ, Ting AY, Carr SA, Luo L. 2022. Transcription factors specify the fate and connectivity of developing neurons. To understand how distal neurites execute commands from these nu...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2022-04-01 | MSV000089187 | MassIVE
TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
TranscriptomicsMicroRNA analysis unravels the molecular basis of bleomycin induced lung fibrosis in mouse
The molecular mechanisms of lung injury and fibrosis are incompletely understood. microRNAs (miRNAs) are crucial biological regulators by suppression of their target genes and are involved in a variety of pathophysiologic processes. To gain insight into miRNAs in the regulation of lung fibrosis, tot...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-24323 | biostudies-arrayexpress
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
UnknownThe Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.
Not available
S-EPMC5593949 | biostudies-literature
UnknownAIM2 in regulatory T cells restrains autoimmune diseases.
Not available
S-EPMC8080937 | biostudies-literature
TranscriptomicsGenome-wide analysis of histone modification, protein-DNA binding, cytosine methylation and transcriptome data in mouse and human ES cells and pig iPS cells
Genome-wide analysis of histone modification (H2AZ, H3K27ac, H3K27me3, H3K36me3, H3K4me1, H3K4me2, H3K4me3 and H3K9me3), protein-DNA binding (TAF1, P300, Pou5f1 and Nanog), cytosine methylation and transcriptome data in mouse and human ES cells and pig iPS cells We generated histone modification da...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-36114 | biostudies-arrayexpress
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