It is a challenging work to screen, identify, and quantify acylcarnitines in complex biological samples. A method, based on the retention time (RT) prediction and data-independent acquisition strategies, was proposed for the large-scale identification of acylcarnitines using liquid chromatography co...
We conducted unbiased mass spectrometric experiments to evaluate the specificity of NCL-ZATAC#20. In these studies, HEK293T cells expressing GFP-NCL were treated with NCL-ZATAC#20. The result revealed the detection of more than 6000 proteins, among which there was a notable degradation of GFP-NCL, c...