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UnknownPharmacological mechanisms of Ma Xing Shi Gan Decoction in treating influenza virus-induced pneumonia: intestinal microbiota and pulmonary glycolysis.
Not available
S-EPMC11331264 | biostudies-literature
TranscriptomicsSynergistic effects of 5-Fluorouracil in combination with Salinomycin promoted ferroptosis via inhibiting SLC7A11/GPX4 in Colorectal Cancer
Purpose: 5-FU resistance is considered to be a possible reason for the failure of conventional drug treatment of colorectal cancer (CRC). Recently, salinomycin (SAL), as a selective inhibitor of cancer stem cells (CSCs), has been used to sensitize and attenuate a variety of solid tumor chemotherapy ...
ORGANISM(S): Homo sapiens 
2025-06-21 | E-MTAB-15206 | biostudies-arrayexpress
ProteomicsInhibition of melanization activation by Serpin-5 and Serpin-9 promotes nucleopolyhedrovirus infection in cotton bollworm Helicoverpa armigera
One of important insect defense mechanisms is melanization, which are mediated by clip domain serine protease (cSP) cascades and regulated by Serpins. In vitro, activation of melanization can efficiently kill Nucleopolyhedrovirus (NPV). However, quantitative proteomics revealed that the infection of...
ORGANISM(S): Helicoverpa armigera (Cotton bollworm) 
2017-09-19 | PXD006126 | Pride
Prophenoloxidase Hemolymph Cotton bollworm Serpin Melanization 
TranscriptomicsTBP ChIP-chip on Jurkat cells
During mitosis, TATA-binding protein(TBP), which remains bound to DNA during mitosis, recruits PP2A and also interacts with a subunit of the condensin complex to allow efficient dephosphorylation and inactivation of condensin near these promoters to inhibit their compaction. These result suggest tha...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-12256 | biostudies-arrayexpress
TranscriptomicsExpression data of WHV/c-myc transgenic mice at preneoplastic and neoplastic stages
The WHV/c-myc transgenic mouse is an animal model of hepatocarcinogenesis that can exquisitely mimic the cancer staging in human Hepatocellular carcinoma (HCC), in which the c-myc oncogene is activated by adjacent woodchuck hepatitis virus (WHV) DNA sequences. Compared to other models of c-myc trans...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-39401 | biostudies-arrayexpress
TranscriptomicsA Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function Understanding the cell-cell interactions that control CNS development and function has long been limited by the lack of methods to cleanly separate astrocytes, neu...
ORGANISM(S): Mus musculus 
2007-12-30 | E-GEOD-9566 | biostudies-arrayexpress
UnknownIdentification of Therapeutic Targets and Prognostic Biomarkers Among Chemokine (C-C Motif) Ligands in the Liver Hepatocellular Carcinoma Microenvironment.
Not available
S-EPMC8685337 | biostudies-literature
MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
TranscriptomicsAdult Human Chondrocyte Response to IL-1B
IL-1B is an important cytokine that is often found to be up-regulated during osteoarthritic and rheumatoid joint diseases. It is viewed as a catabolic factor, inducing enzymes that allow for the degradation of the cartilage extracellular matrix and also has essential roles as an autocrine and parac...
ORGANISM(S): Homo sapiens 
2008-05-14 | E-GEOD-11427 | biostudies-arrayexpress
UnknownEpigenetic and Posttranscriptional Modulation of SOS1 Can Promote Breast Cancer Metastasis through Obesity-Activated c-Met Signaling in African-American Women.
Not available
S-EPMC8178187 | biostudies-literature
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