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The silkworm silk gland is one of the most efficient protein synthesis systems among all organisms. Its amazingly efficient protein synthesis makes the silk gland a desirable object for basic studies on gene expression and regulation and for biotechnological applications. At the early stages of the ...
ORGANISM(S): Bombyx mori 
We reveal a negative association between Human Papillomavirus (HPV)-encoded circular RNA, circE7, and the infiltration of CD8+ T cells in head and neck squamous cell carcinoma (HNSCC). Both in vitro and in vivo experiments demonstrate that circE7 suppresses the function and activity of T cells by do...
ORGANISM(S): Homo sapiens (Human) 
2024-09-06 | PXD055003 | Pride
Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with genetic factors playing a significant role in its occurrence. The HLA gene region on chromosome 6 is linked to NPC susceptibility, but the mechanisms remain unclear. Epstein-Barr virus (EBV) infection is a well-established ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD074503 | Pride
Sustainable production of plant secondary metabolites remains a significant challenge. Engineered yeast platforms offer a promising alternative, yet reconstituting plant cytochrome P450s (CYPs), key enzymes in these pathways, remains a major burden. Plant Membrane-Steroid-Binding Proteins (MSBPs) ha...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-09-22 | PXD060429 | Pride
The temporal lobe is the cerebral cortex with critical function. The superior and middle gyrus of temporal lobe have been well studied, however, present perceptions on inferior temporal gyrus remains limited. The understanding of age-related protein profile change in human inferior temporal gyrus ha...
ORGANISM(S): Homo sapiens (Human) 
2015-12-07 | PXD002528 | Pride
The deposition of amyloid senile plaques (SPs) play a central role in Alzheimer’s disease (AD), but the mechanisms by which SPs induce neural toxicity are disputed. Genetically engineered mouse models emphasising SPs have had limited success in reproducing the neuropathology of AD, and have also fai...
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD005824 | Pride
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