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TranscriptomicsNKp44/HLA-DP-dependent regulation of CD8 T cell clonality by NK cells
NK cells are increasingly recognized for their modulation of adaptive T cell responses; however the mechanisms by which NK cells modulate immune responses in human are unclear. Here we report that NKp44+ NK cells regulate CD8+ T cell expansion in an HLA-DP haplotype-dependent process. HLA-DP express...
ORGANISM(S): Homo sapiens 
2025-10-10 | E-MTAB-13405 | biostudies-arrayexpress
ProteomicsHLA class II ligandome from HOM-2 and JY cell lines (HLA-DR an HLA-DP ligands)
A high-throughput mass spectrometry analysis was used to identify more than 16,000 cell peptides bound to several HLA-DR and -DP class II molecules isolated from large amounts of two human cell lines (HOM-2 and JY).
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028006 | Pride
Hla-dr Hla-dp 
ProteomicsPromiscuity of peptides presented in HLA-DP molecules from different immunogenicity groups is associated with T-cell cross-reactivity
In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-DP alleles can provoke profound allo-HLA-DP-specific immune responses from the donor T-cell repertoire leading to graft-versus-leukemia effect and/or graft-versus-host disease in the patient. The magnitude of al...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD030591 | Pride
Allosct Dpc-classification Cd4 t-cell clones Peptidome Hla-dp Cross-reactivity 
ProteomicsT-cell alloreactivity to HLA-DP is regulated by peptide repertoire divergence and HLA-DM mediated editing
Analysis of the peptide repertoires eluted from different HLA-DP molecules expressed in HeLa cells co-expressing Invariant chain either with or without HLA-DM as components of the HLA class II processing machinery. Divergence of the immunopeptidomes and the impact of HLA-DM were investigated in rela...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD017154 | Pride
Hla class ii Hla-dm Immunopeptidome Hla-dp T-cell alloreactivity 
ProteomicsHigh-risk EBV promotes immune evasion in nasopharyngeal carcinoma by upregulating HLA-DP via the encoded BALF2-HR variant
Nasopharyngeal carcinoma (NPC) is prevalent in East and Southeast Asia, with genetic factors playing a significant role in its occurrence. The HLA gene region on chromosome 6 is linked to NPC susceptibility, but the mechanisms remain unclear. Epstein-Barr virus (EBV) infection is a well-established ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD074503 | Pride
Nasopharyngeal carcinoma Immune evasion Balf2 High-risk ebv subtype Hla-dp 
GenomicsNKp44/HLA-DP-dependent regulation of CD8 T cell clonality by NK cells
NKp44/HLA-DP-dependent regulation of CD8 T cell clonality by NK cells
PRJEB66421 | ENA
ProteomicsFVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4
The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) poses a major challenge in hemophilia A (HA) treatment. The formation of FVIII inhibitors is a CD4+ T-cell-dependent mechanism which includes anti- gen presenting cells (APC), B- and T-helper lymphocytes....
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD069096 | Pride
Hemophilia a Inhibitors Immunity Factor viii 
ProteomicsAccurate prediction of antigen presentation for HLA class II across loci using tailored data acquisition and refined machine learning
Accurate prediction of antigen presentation by Human Leukocyte Antigen (HLA) class II molecules is crucial for rational development of immunotherapies and vaccines targeting CD4 T cell activation. So far, most prediction methods for HLA class II antigen presentation have focused on HLA-DR due to lim...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD044810 | Pride
Hla-class ii Netmhciipan-4.3 Antigen presentation Machine learning Hla-dp 
Genomics
Novel HLA-DP Alleles
PRJEB35695 | ENA
UnknownHLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.
Not available
S-EPMC3003381 | biostudies-literature
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