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ProteomicsT-cell alloreactivity to HLA-DP is regulated by peptide repertoire divergence and HLA-DM mediated editing
Analysis of the peptide repertoires eluted from different HLA-DP molecules expressed in HeLa cells co-expressing Invariant chain either with or without HLA-DM as components of the HLA class II processing machinery. Divergence of the immunopeptidomes and the impact of HLA-DM were investigated in rela...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD017154 | Pride
Hla class ii Hla-dm Immunopeptidome Hla-dp T-cell alloreactivity 
ProteomicsHLA-DM-mediated HLA-DR3 Immunopeptidome
T2 cells stably expressing HLA-DR3 and variable amounts of HLA-DM (none, low, and high, per GFP co-expression) were lysed and HLA-DR3-peptide complexes were isolated via immunoprecipitation. Antigenic peptides were then eluted and quantified by LC-MS/MS to assess presented antigenic epitopes.
ORGANISM(S): Homo sapiens (Human) 
2018-04-16 | PXD008775 | Pride
Hla-dr Hla-dm Immunopeptidome 
ProteomicsTuning DO:DM ratios modulates HLA class II immunopeptidomes
Major Histocompatibility Complex Class II antigen presentation underlies a wide range of immune responses in health and disease. Although peptide ligand binding affinity has been the major focus for explaining and predicting class II antigens, we know that the levels and activities of accessory mol...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD024392 | Pride
Hla-ii Mhc Dm Antigen presentation Do Orbitrap 
ProteomicsHLA-DM allotypes - Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation
Major Histocompatibility Complex of Class II (MHCII) antigen presentation is a key event of adaptive immunity. HLA-DM favors the presentation of kinetically stable peptide-MHCII complexes but does not bind peptides itself and exhibits only a low degree of polymorphism. To date, no evidence for alter...
ORGANISM(S): Homo sapiens (Human) 
2018-10-31 | PXD009791 | Pride
Antigen presentation/ mhc class ii/ immunopeptidome/ peptide editing/ polymorphism 
UnknownpH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.
Not available
S-EPMC4661524 | biostudies-literature
UnknownHLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.
Not available
S-EPMC3944065 | biostudies-literature
UnknownHLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.
Not available
S-EPMC3003381 | biostudies-literature
UnknownIdentification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis.
Not available
S-EPMC2193930 | biostudies-literature
UnknownMapping the HLA-DO/HLA-DM complex by FRET and mutagenesis.
Not available
S-EPMC3396517 | biostudies-literature
UnknownCrystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.
Not available
S-EPMC3530167 | biostudies-literature
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