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MetabolomicsMetabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM

Most of pre-diabetes were eventually progress to diabetes, thereby profiling of prediabetic metabolic disorders may be an effective targeted preventive measure. We aimed to elucidate internal motivation of the progression of pre-diabetes to type 2 diabetes mellitus (T2DM) from a metabolic perspec...

2024-04-29 | MTBLS8644 | MetaboLights
MetabolomicsZhaqu Compound Improves Glucose and Lipid Metabolism in T2DM with MASLD by Modulating Gut Microbiota and PPARγ

Type 2 diabetes mellitus (T2DM) with metabolic syndrome-associated steatohepatitis (MASLD) is a complex metabolic comorbidity characterized by hyperglycemia, pancreatic β-cell dysfunction, and hepatic lipid metabolism disorders, in which gut microbiota dysbiosis and abnormal PPARγ signaling play ...

2026-02-25 | MTBLS13933 | MetaboLights
MetabolomicsEffects of herb DG and KK01 on Type 2 Diabetes Mellitus (T2DM) through Lipidomics
Not available
ORGANISM(S): Mus musculus 
ST000530 | MetabolomicsWorkbench
ProteomicsTuning DO:DM ratios modulates HLA class II immunopeptidomes
Major Histocompatibility Complex Class II antigen presentation underlies a wide range of immune responses in health and disease. Although peptide ligand binding affinity has been the major focus for explaining and predicting class II antigens, we know that the levels and activities of accessory mol...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD024392 | Pride
Hla-ii Mhc Dm Antigen presentation Do Orbitrap 
ProteomicsT-cell alloreactivity to HLA-DP is regulated by peptide repertoire divergence and HLA-DM mediated editing
Analysis of the peptide repertoires eluted from different HLA-DP molecules expressed in HeLa cells co-expressing Invariant chain either with or without HLA-DM as components of the HLA class II processing machinery. Divergence of the immunopeptidomes and the impact of HLA-DM were investigated in rela...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD017154 | Pride
Hla class ii Hla-dm Immunopeptidome Hla-dp T-cell alloreactivity 
GenomicsEnterococcus mundtii strain:Dm
Enterococcus mundtii strain:Dm Genome sequencing and assembly
PRJNA1195720 | ENA
ProteomicsHLA-DM-mediated HLA-DR3 Immunopeptidome
T2 cells stably expressing HLA-DR3 and variable amounts of HLA-DM (none, low, and high, per GFP co-expression) were lysed and HLA-DR3-peptide complexes were isolated via immunoprecipitation. Antigenic peptides were then eluted and quantified by LC-MS/MS to assess presented antigenic epitopes.
ORGANISM(S): Homo sapiens (Human) 
2018-04-16 | PXD008775 | Pride
Hla-dr Hla-dm Immunopeptidome 
GenomicsStreptomyces coeruleorubidus strain:DM | isolate:Shanghai
Streptomyces coeruleorubidus strain:DM | isolate:Shanghai Genome sequencing
PRJNA936494 | ENA
ProteomicsDM
Diabetic mellitus (DM) is a disease that affects glucose homeostasis and has cause of complications, such as diabetic nephropathy (DN). For diagnose of the early DN, microalbuminuria is one of the mostly used biomarker currently. However, more early diagnostic biomarkers are desired rather than micr...
ORGANISM(S): Homo Sapiens (human) 
2018-05-31 | PXD008683 | JPOST Repository
GenomicsLeuconostoc mesenteroides strain:DM-1210
Leuconostoc mesenteroides strain:DM-1210 Genome sequencing
PRJNA1091794 | ENA
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