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ProteomicsBicyclol attenuates high fat diet-induced nonalcoholic fatty liver disease/nonalcoholic steatohepatitis through modulating multiple pathways in mice.
The pathological progression of nonalcoholic fatty liver disease (NAFLD) is driven by multiple factors, and nonalcoholic steatohepatitis (NASH) represents its progressive form. In our previous studies, we found that bicyclol had beneficial effects on NAFLD/NASH. Here we aim to investigate the underl...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-23 | PXD040233 | Pride
Bicyclol Multiple pathways Proteomics Nafld Nash 
ProteomicsSOD1 is a possible predictor of COVID-19 progression as revealed by plasma proteomics
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide health emergency. Patients infected with SARS-CoV-2 present with diverse symptoms relating to the severity of the disease. Determining the proteomic changes ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-05 | PXD024728 | Pride
Covid-19 Tmt Plasma Sod1 
ProteomicsLysosome-autophagy dysfunction contribute to TDCIPP induced Aβ1-42 production in N2a-APPswe cells.
Alzheimer's disease is the most common form of dementia characterized on cognitive impairment. Autophagy-lysosome dysfunction is linked to AD pathology. Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used organophosphorus flame retardants with the potential to induce neuronal damage. We...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042789 | Pride
Abeta42  stat1  alzheimer disease autophagy 
ProteomicsQuantitative Proteomic Analysis Reveals potential roles of PRDX3 for neurite outgrowth in N2a-APPswe Cells
Alzheimer’s disease (AD) is characterized by amyloid plaques and neurofibrillary tangles accompanied with progressive neurite loss. Mitochondria play pivotal roles in Alzheimer’s disease development. PRDX3 is a mitochondrial peroxide reductase responsible for H2O2 scavenge and signaling transduction...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-24 | PXD032733 | Pride
Prdx3 Neurite Mitochondria 
ProteomicsA quantitative proteomic study reveals oxidative stress and synaptic loss contributed to TDCIPP exposure induced memory impairment (2)
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been consistently identified in various environmental media and biological specimens. The current understanding of the in vivo toxicities of TDCIPP remains limited, especially for its neurotoxicity and cognitive impairment effects. To better evaluat...
ORGANISM(S): Rattus Rattus 
PXD045959 |
ProteomicsProteomics Study of Molecular Mechanisms Involved in Early Pregnancy Loss
To identify the proteins and molecular signaling pathways that contribute to EPL, we performed proteomics and bioinformatics analysis of the placental villi in women who have undergone EPL and in normal pregnant women.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080693 | MassIVE
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080710 | MassIVE
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