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ProteomicsRIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity
The 53BP1-RIF1 pathway antagonizes resection of DNA broken ends and confers PARP inhibitor sensitivity on BRCA1-mutated tumors. However, it is unclear how this pathway suppresses initiation of resection. Here, we identify ASF1 as a partner of RIF1 via an interacting manner similar to its interaction...
ORGANISM(S): Homo sapiens (Human) 
2022-02-04 | PXD031311 | Pride
Hek293t Lc-ms Human 
TranscriptomicsTop3M-NM-2 is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation
Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3M-NM-2 (Top3M-NM-2) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein deficient in Fragile X syndrome and know...
ORGANISM(S): Homo sapiens 
2013-08-04 | E-GEOD-47502 | biostudies-arrayexpress
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