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AML is a prevalent hematologic neoplasms disease. Around 13% AML patients harbor somatic mutations in cohesin complex genes. We performed IP-MS and detected SMC3-interacting proteins in OCI-AML3 cells.
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD061209 | Pride
Copy number variation (CNV) is important and widespread in the genome, and is a major cause of disease and phenotypic diversity. Herein, we perform a genome-wide analysis of CNVs in the 12 diversified chicken genomes based on next-generation sequencing. We apply aCGH experiments to confirm our predi...
ORGANISM(S): Gallus gallus 
Copy number variation (CNV) is important and widespread in the genome, and is a major cause of disease and phenotypic diversity. Herein, we perform a genome-wide analysis of CNVs in the 12 diversified chicken genomes based on next-generation sequencing. We apply aCGH experiments to confirm our predi...
ORGANISM(S): Gallus gallus 
We used IP-MS to detected the proteins that interact with ESCO2 in response to DNA damage.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039072 | Pride
PS is one of the most difficult plastics to degrade, and its microplastic residues have been detected in various environments.
ORGANISM(S): Cupriavidus Sp. D4 
2025-12-28 | PXD072476 |
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
This project identified the interacting proteins of p53 under glucose starvation in HEK293 cells.
ORGANISM(S): Homo Sapiens 
2023-04-04 | PXD041361 |
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
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