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ProteomicsLRRK2-RAB12 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes
Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases and this phosphorylation is elevated by Parkinson’s disease (PD)-linked mutations of LRRK2. However, the precise function of the specific RAB GTPase targeted by LRRK2 signaling remains to be elucidated. Here we solve the str...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-18 | PXD048732 | Pride
Structure of lrrk2-rab12 protein complex Proteomics Lrrk2 Ciliogenesis Centrosome homeostasis Parkinson’s disease Tandem mass tag 
ProteomicsThe multiomics landscape of serum exosomes during the development of sepsis
Our study describes the landscape of the molecular dynamics of serum exosomes during the development of sepsis and proposes some hypothetical molecular mechanisms, which may provide helpful diagnostic and therapeutic insights for the ongoing battle against sepsis.
ORGANISM(S): Homo Sapiens 
2021-04-11 | PXD025311 |
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