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ProteomicsPlasma Proteomic Characterization of Colorectal Cancer Patients with FOLFOX Chemotherapy
Colorectal Cancer (CRC) is one of most common cancers in the world and a main treatment in postoperative chemotherapy is oxaliplatin and fluorouracil (FOLFOX), But the effect is different among CRC patients. In this study, LC-MS/MS strategy was used to profile the plasma proteome in FOLFOX benefit a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044201 | Pride
Human plasma proteome  sisprot  lc-ms/ms  random forest  prm validation 
UnknownCavity-altered superconductivity.
Is it feasible to alter the ground-state properties of a material by engineering its electromagnetic environment? Inspired by theoretical predictions1-12, experimental realizations of such cavity-controlled properties without optical excitation are beginning to emerge13-19. Her...
S-EPMC12935536 | biostudies-literature
Proteomicsthe function of RNA Binding Protrein in cancer
RNA Binding Protrein plays of vital imortance in cancer progression.
ORGANISM(S): Homo Sapiens 
2021-12-08 | PXD022776 |
ProteomicsTargeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy
Proteomic profiling of differentially expressed proteins of 4T1 cells induced by liposome.
ORGANISM(S): Mus Musculus 
2026-02-03 | PXD073979 |
Proteomics- Identification of Gαi2-interacting proteins via affinity pull-down and quantitative mass-spectrometry analysis.
In studying patients with activating GNAI2 mutations, we observed T cell hyperresponsiveness that was independent of cAMP suppression. Therefore, we hypothesized that Gαi2 utilizes alternative signal transduction pathways which might be delineated by identifying its interacting proteins in T cells. ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-09-20 | PXD048980 | Pride
Gpcrs G-protein coupled receptors Gnai2 - gαi2 G-protein 
UnknownMutations disrupting neuritogenesis genes confer risk for cerebral palsy.
In addition to commonly associated environmental factors, genomic factors may cause cerebral palsy. We performed whole-exome sequencing of 250 parent-offspring trios, and observed enrichment of damaging de novo mutations in cerebral palsy cases. Eight genes had multiple damaging de novo mutations; o...
S-EPMC9148538 | biostudies-literature
UnknownGermline mutations in a G protein identify signaling cross-talk in T cells.
Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric G protein signal transduction usually thought to regulate a...
S-EPMC11811912 | biostudies-literature
UnknownComprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses.
We report the results of a comprehensive copy number variant (CNV) reanalysis of 9171 exome sequencing datasets from 5757 families affected by a rare disease (RD). The data reanalysed was extremely heterogeneous, having been generated using 28 different enrichment kits by 42 different research group...
S-EPMC11513043 | biostudies-literature
UnknownGlobal, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Not available
S-EPMC4202387 | biostudies-literature
UnknownAn interconnected data infrastructure to support large-scale rare disease research.
The Solve-RD project brings together clinicians, scientists, and patient representatives from 51 institutes spanning 15 countries to collaborate on genetically diagnosing ("solving") rare diseases (RDs). The project aims to significantly increase the diagnostic success rate by co-analyzing data from...
S-EPMC11413801 | biostudies-literature
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