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MetabolomicsTranscriptome and metabolome changes in Chinese cedar during cold acclimation reveal the roles of flavonoids in needle discoloration and cold resistance

Cryptomeria fortunei growth and development are usually affected by low temperatures. Despite the evergreen nature of this species, most needles turn yellowish-brown in cold winters. The underlying discoloration mechanisms that cause this phenomenon in response to cold acclimation remain...

2022-08-12 | MTBLS3184 | MetaboLights
ProteomicsiTRAQ-based analysis of muscle mitochondria isolated from LONP1-mKO mice
This experiment was conducted to identify the mitochondrial protein changes in the presence and absence of LONP1 in skeletal muscle. The following abstract from the submitted manuscript describes the major findings of this work.Disuse-associated loss of muscle LONP1 impairs mitochondrial quality and...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-05 | PXD029722 | Pride
Mouse Skeletal muscle 
UnknownBehavioural deficits of autism spectrum disorder and associations with different gene clusters: a study with the whole-genome transmission disequilibrium test.
Not available
S-EPMC10335436 | biostudies-literature
UnknownCDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity.
Not available
S-EPMC6604390 | biostudies-literature
UnknownEfficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial.
Not available
S-EPMC6324088 | biostudies-literature
ProteomicsURI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers. HEK293T cells were transfected with His-URI plasmid before anti-His immunoprecipitation and gel cutting. LC-MS/MS was performed to identify URI potential binding proteins.
URI keeps low levels of p53 in a TRIM28-MDM2 dependent manner, maintains SCD1 activity and accumulation of MUFAs, and subsequently promotes resistance to TKIs in cancer cell. URI-p53-SCD1 axis mediates resistance of TKIs and may explain why p53-wild type HCC still showed intrinsic resistance to TKIs...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD045407 | Pride
Uri 
UnknownEnhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds.
Not available
S-EPMC6362571 | biostudies-literature
MetabolomicsTranscriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons

Cryptomeria fortunei (Chinese cedar) has outstanding medicinal value due to its abundant flavonoid and terpenoid contents. The metabolite contents of C. fortunei needles differ across different seasons. However, the biosynthetic mechanism of these differentially synthesized meta...

2022-08-12 | MTBLS4099 | MetaboLights
ProteomicsTargeting WTX-P54nrb Phase Separation Sensitizes Chemotherapy in Gastric Cancer
To provide insights into any distinctions between the cellular functions of WTX-S and WTX-L, we defined their protein interaction networks by performing liquid chromatography–tandem MS of affinity-purified protein complexes.
ORGANISM(S): Homo Sapiens 
2024-10-23 | PXD057127 |
UnknownSystematic assessment of structural variant annotation tools for genomic interpretation.
Not available
S-EPMC11632063 | biostudies-literature
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