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TranscriptomicsGlobal Gene Expression analysis of CUTLL1 cell lines after treatment with Perhexiline
We identify perhexiline, a small molecule inhibitor of mitochondrial carnitine palmitoyltransferase-1, as a HES1-signature antagonist drug with robust antileukemic activity against NOTCH1 induced leukemias in vitro and in vivo. RNA-Seq from CUTLL1 cell lines treated with Perhexiline or vehicle for 3...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-66014 | biostudies-arrayexpress
TranscriptomicsExpression data from Hes1 conditional knock-out NOTCH1-induced leukemias
To formally address the biological activity of Hes1 in vivo, we tested the interaction between oncogenic NOTCH1 and acute Hes1 loss in a retroviral-transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full leuk...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-65863 | biostudies-arrayexpress
TranscriptomicsExpression data from CUTLL1 cells infected with shHES1
To formally address the biological activity of HES1 in vitro, we measured the transcriptional effect of HES1 inactivation infectiing CUTLL1 leukemia cell lines with shHES1 HES1 knockdown triggered apoptosis in human T-ALL lymphoblasts. We show that HES1 inactivation induces programmed cell death in ...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-65872 | biostudies-arrayexpress
UnknownMeasurement of Carcinoembryonic Antigen in Clinical Serum Samples Using a Centrifugal Microfluidic Device.
Not available
S-EPMC6187594 | biostudies-literature
TranscriptomicsKnock out of NOTCH1-bound MYC putative enhancer (N-Me)
Analysis of Gene Expression in KO mice lacking the NOTCH1-bound MYC putative enhancer located at +1.43K downstream of the MYC gene. Enrichment of MYC signature genes were analyzed by GSEA. Results show that MYC expression signature is indeed significantly enriched. Conditional Knockout or WT mice we...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-57988 | biostudies-arrayexpress
TranscriptomicsExpression data from isogenic Pten WT mouse T-ALLs infected with MSCV Myr-AKT-IRES-mCherry or empty vector, treated with DBZ or DMSO
To explore the mechanisms downstream of NOTCH1 and PTEN in the control of leukemia cell growth, we performed expression profiling on NOTCH1 induced and Pten-positive T-ALL tumor cells infected with constitutively active AKT (myristoylated-AKT). Constitutive activation of AKT rescues the transcriptio...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71089 | biostudies-arrayexpress
ProteomicsA comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster
We present the first comprehensive proteomic and phosphoproteomic atlas of nine major organs of the Chinese hamster (Cricetulus griseus). A total of 14,219 proteins, 11,828 phosphorylated proteins, and 47,122 phosphorylation sites were identified, revealing distinct inter-organ molecular features.
ORGANISM(S): Cricetulus Griseus 
2025-10-04 | PXD069241 |
TranscriptomicsExpression data from isogenic Pten WT or KO mouse T-ALLs treated with DBZ or DMSO
To investigate the underlying mechanisms mediating resistance to NOTCH inhibition in Pten-null T-ALL tumor cells we performed gene expression profiling of isogenic Pten-positive and Pten-deleted leukemia lymphoblasts after acute treatment with DBZ in vivo. This analysis revealed that, while direct N...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71087 | biostudies-arrayexpress
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