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TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension (Illumina)
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-21097 | biostudies-arrayexpress
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20206 | biostudies-arrayexpress
UnknownSelective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.
Not available
S-EPMC3866029 | biostudies-literature
GenomicsThe histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis
Despite correlations between histone methyltransferase (HMT) activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histone H3 lysine 4 (H3K4) methyltransferase critical for maintaining hematop...
ORGANISM(S): Mus musculus 
2014-04-03 | E-GEOD-56456 | biostudies-arrayexpress
UnknownLapatinib-Related Rash and Breast Cancer Outcome in the ALTTO Phase III Randomized Trial.
Not available
S-EPMC5017935 | biostudies-literature
GenomicGWAS of Preterm Birth

Preterm birth (PTB, born before 37 weeks of gestation) is a leading cause of neonatal mortality and post-natal morbidity. PTB affects one in nine all live births in the U.S. Notably, the highest rate of PTB occurs among African Americans (one in six). PTB is a complex trait, likely determined by ...

phs000332 | dbGaP
TranscriptomicsTranscription profiling of rat lung to investigate trauma hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes
The etiology of trauma-hemorrhage shock-induced acute lung injury has been difficult to elucidate due, at least in part, to the inability of in vivo studies to separate the non-injurious pulmonary effects of trauma-hemorrhage from the tissue injurious ones. To circumvent this in vivo limitation, we...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6332 | biostudies-arrayexpress
GenomicsGenome Sequencing of Pancreatic Ductal Adenocarcinoma at The Human Genome Sequencing Center of Baylor College of Medicine (HGSC-BCM)

Pancreatic ductal adenocarcinomas (PDAC) is the 11th most common cancer in the USA but the 4th in fatalities. The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. We combined our capability to capture and enrich exome DNA with the next generation se...

phs000516.v1.p1 | EGA
UnknownAdjuvant Anti-HER2 Therapy, Treatment-Related Amenorrhea, and Survival in Premenopausal HER2-Positive Early Breast Cancer Patients.
Not available
S-EPMC6335113 | biostudies-literature
TranscriptomicsTranscription profiling of skin samples from atopic dermatitis patients before and after treatment with cyclosporine A
After 2 and 12 weeks of treatment, we observed significant reductions of 51% and 72%, respectively, in SCORAD scores. Clinical improvements were associated with significant gene expression changes in lesional but also nonlesional skin, particularly reductions in levels of TH2-, TH22-, and some TH17-...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-58558 | biostudies-arrayexpress
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