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UnknownAdjuvant sorafenib after heptectomy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma patients.

Aim

To investigate the efficacy and safety of adjuvant sorafenib after curative resection for patients with Barcelona Clinic Liver Cancer (BCLC)-stage C hepatocellular carcinoma (HCC).

Methods

Thirty-four HCC patients, classified as BCLC-stage C, received adjuvant sorafenib for high-r...
S-EPMC4910659 | biostudies-literature
UnknownEfficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study.

Aim

To assess the efficacy and safety of a Chinese herbal medicine (CHM), Xiangsha Liujunzi granules, in the treatment of patients with functional dyspepsia (FD).

Methods

We performed a randomized, double-blind, placebo-controlled trial with patients from three centers. Two hundred an...
S-EPMC5558122 | biostudies-literature
ProteomicsQuantitative Proteomic Analysis Identifies IGFBP5 as a Secreted Marker for ASCL1High Pulmonary Neuroendocrine Tumors
Lung cancer is the leading cause of cancer death in the United States. Among the various subtypes of lung cancers, pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC) and NE-non-small cell lung cancer (NE-NSCLC), is a particularly aggressive malignancy that is distinct from...
ORGANISM(S): Homo sapiens (Human) 
2019-07-22 | PXD013267 | Pride
Neuroendocrine lung cancer Ascl1 Proteomics and mass spectrometry Secretome Small cell lung cancer 
ProteomicsQuantitative Proteomic Analysis Identifies IGFBP5 as a Secreted Marker for ASCL1High Pulmonary Neuroendocrine Tumors
Lung cancer is the leading cause of cancer death in the United States. Among the various subtypes of lung cancers, pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC) and NE-non-small cell lung cancer (NE-NSCLC), is a particularly aggressive malignancy that is distinct from...
ORGANISM(S): Homo sapiens (Human) 
2019-07-03 | PXD013298 | Pride
Neuroendocrine lung cancer Ascl1 Proteomics and mass spectrometry Secretome Small cell lung cancer 
ProteomicsQuantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification
The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of ly...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031543 | Pride
Phosphoproteomics stk11ip 
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer (batch2-6)
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029968 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029972 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
UnknownInsufficient Dose of ERCC8 Protein Caused by a Frameshift Mutation Is Associated With Keratoconus With Congenital Cataracts.

Purpose

The purpose of this study was to identify a new candidate gene for keratoconus and congenital cataracts and further investigate its underlying pathogenic mechanisms.

Methods

This study, using a Chinese family with keratoconus and congenital cataracts, 262 patients with sporadi...
S-EPMC9728497 | biostudies-literature
UnknownRandomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma.

Purpose

To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced resectable oral squamous cell carcinoma (OSCC).

Patients...

S-EPMC5569675 | biostudies-literature
ProteomicsIntegrated Proteogenomic Characterization of Adenocarcinoma of the esophagogastric junction
In this study, we performed comprehensive genomic, transcriptomic, proteomic, and phosphorylation analysis of tumor tissues and paired normal adjacent tissues (NATs) of AEG. we describe integrative proteogenomic analyses of the largest cohort to date of AEG samples that focused particularly on novel...
ORGANISM(S): Homo sapiens (Human) 
2022-11-14 | PXD030725 | Pride
Adenocarcinoma of the esophagogastric junction，aeg，lc-ms/ms Proteogenomic 
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