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GenomicsChIP-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Gene expression is balanced by transcription and mRNA degradation. Shortening of polyadenosine (poly(A)) tails (deadenylation) is the initial step in the decay of most mRNAs. However, the mechanism by which deadenylation controls mRNA expression is not fully understood. This experiment aimed to dete...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-5887 | biostudies-arrayexpress
TranscriptomicsRIP-seq of livers in C57BL/6J mice with antibodies against Cnot3, Ago2, and BRF1
Shortening of polyadenosine (poly(A)) tails (deadenylation) is the initial step in the decay of most mRNAs. The CCR4-NOT complex is the major deadenylase in mammals. Interaction of Cnot1 with RNA binding proteins, including the miRNA-induced silencing complex (miRISC), which includes Argonaute (Ago)...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-6941 | biostudies-arrayexpress
TranscriptomicsRNA-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice
Gene expression is balanced by transcription and mRNA degradation. Shortening of polyadenosine (poly(A)) tails (deadenylation) is the initial step in the decay of most mRNAs. However, the mechanism by which deadenylation controls mRNA expression is not fully understood. This experiment aimed to dete...
ORGANISM(S): Mus musculus 
2020-03-30 | E-MTAB-5901 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse keratinocytes expressing AhR to investigate inflammatory responses
Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to provoke inflammatory and/or allergic disorders including asthma, rhinitis and dermatitis. The molecular mechanisms of this PAH-mediated inflammation remain to be clarified. Previous studies imp...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2955 | biostudies-arrayexpress
TranscriptomicsRoles of mRNA decay in liver development
mRNA decay machineries play important roles in various biological events. Among them, Cnot deadenylase complex has a critical function to trigger mRNA decay. To understand roles of the complex in liver development, we compare RNA expression between control and Cnot complex-deficient liver.
ORGANISM(S): Mus musculus 
2019-02-01 | E-MTAB-7182 | biostudies-arrayexpress
GenomicsGenome-wide localization of NF-E2 p45 in mouse primary megakaryocytes.
ChIP-seq assay was performed with anti-p45 antibody using in vitro cultured primary megakaryocytes to identify direct p45 target genes in megakaryocytes. This analysis revealed genes that regulate platelet function, which were not known previously to be p45-regulated. ChIP was performed using a day...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-42249 | biostudies-arrayexpress
UnknownHox/Meis-dependent gene-regulatory transition underlies cardiopharyngeal neural crest diversification
Not available
S-SCDT-10_1038-S44318-026-00886-X | biostudies-other
ProteomicsFFPE proteome analysis of non-cancer lesion of renal cell carcinoma
To extract the molecules that correlate with kidney function and fibrosis, we performed the proteome analysis of non-cancer lesion of renal cell carcinoma in 16 patients. Proteins were extracted from FFPE slice samples and digested using the SP3 method as previously described. The digested peptide s...
ORGANISM(S): Homo Sapiens (human) 
2025-10-21 | PXD060453 | JPOST Repository
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