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UnknownEpigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.
Not available
S-EPMC4768123 | biostudies-literature
TranscriptomicsExpression profiling of 36 types of normal human tissues to identify tissue-specific genes
We performed expression profiling of 36 types of normal human tissues and identified 2,503 tissue-specific genes. We then systematically studied the expression of these genes in cancers by re-analyzing a large collection of published DNA microarray datasets. Our study shows that integration of each ...
ORGANISM(S): Homo sapiens 
2005-04-03 | E-GEOD-2361 | biostudies-arrayexpress
TranscriptomicsGene repression with H3K27me3 modification in human small cell lung cancer
Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis due to early dissemination and rapid growth. We here analyze gene expression profile of 23 clinical SCLC samples. EZH2 was found to be highly expressed in SCLC samples compared to 42 normal tissues including the normal lun...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-43346 | biostudies-arrayexpress
TranscriptomicsExpression data of HUVEC cells after PPARβ/δ agonist and/or hypoxia treatment
Recently the role of PPARβ/δ in angiogenesis has been revealed, and we hypothesized that the crosstalk between hypoxia and PPARβ/δ on endothelial cells may exsist. To elucidate the interaction between two signalings, we report the comprehensive change of transcripts induced by PPARβ/δ agonist (GW501...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-50378 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K27ac, PPARβ/δ and Pol II localization in HUVECs
H3K27Ac is one of the expressed enhancer markers, PPARβ/δ is a transcription factor and Pol II (RNA polymerase II) is an enzyme which catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. These genomic localization in endothelial cells is unknown in endothe...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-50144 | biostudies-arrayexpress
GenomicsGenome-wide maps of MEF2C and H3K27ac localization in HUVECs
MEF2C is one of the substantially expressed transcriptional factors in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for MEF2C, and performed ChIP-seq to identify MEF2C binding site in whole genome manner. H3K27Ac binding sites were also detec...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32644 | biostudies-arrayexpress
GenomicsGenome-wide binding sites of Hypoxia inducible factor 1 (HIF1) and histone modifications
We report the high-throughput profilings of HIF1 and histone modifications in human umbilical vein endothelial cells (HUVEC). By obtaining over two billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of HUVEC under normoxia and hypoxia. We f...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39089 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K27ac localization in HUVECs
H3K27Ac is one of the expressed enhancer markers in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for H3K27ac, and performed ChIP-seq to identify H3K27ac binding site in whole genome manner under hypoxia. We used chromatin immunoprecipitation w...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-38555 | biostudies-arrayexpress
GenomicsGenome-wide maps of RNA Polymerase II and p65 localization in HUVECs stimulated with TNF alpha
TNF alpha is one of the inflammatory mediator and induce genes mainly by transcriptional factor, p65, in endothelial cells. This time, we performed a time course study to detect the change of localization of p65 and Pol II. To identify p65 and Pol II binding sites, we used chromatin immunoprecipit...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-34500 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of gastric cancer by oligonucleotide microarrays
To gain molecular understanding of carcinogenesis, progression, and diversity of gastric cancer, 22 primary human advanced gastric cancer tissues and 8 noncancerous gastric tissues were analyzed by high-density oligonucleotide microarray in this study. Based on expression analysis of approximately 6...
ORGANISM(S): Homo sapiens 
2005-05-22 | E-GEOD-2685 | biostudies-arrayexpress
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