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TranscriptomicsSubtherapeutic antibiotics alter the murine colonic microbiome and early life adiposity
Early life exposure to antibiotics alters the gut microbiome. These alterations lead to changes in metabolic homeostasis and an increase in host adiposity. We used microarrays to identify metabolic genes that may be up- or down-regulated secondary to antibiotic exposure. Low dose antibiotics have be...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-38880 | biostudies-arrayexpress
TranscriptomicsAltering the intestinal microbiota during a critical developmental window has lasting metabolic consequences [RNA-Seq]
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), ...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-58089 | biostudies-arrayexpress
TranscriptomicsMetabolic and metagenomic outcomes from early-life pulsed antibiotic treatment
Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-68603 | biostudies-arrayexpress
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