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TranscriptomicsComparison of expression profiles of Foxp3(+)epigenetics(-) T cells, Foxp3(-)epigenetics(+) T cells, and Foxp3(+)epigenetics(+) T cells
Analysis of Foxp3(+)epigenetics(-) T cells, Foxp3(-)epigenetics(+) T cells, and Foxp3(+)epigenetics(+) T cells. Results indicate regulatory T cell (Treg) ontogenesis requires two independent processes, expression of the transcription factor Foxp3 and establishment of Treg epigenetic programs induced...
ORGANISM(S): Mus musculus 
2012-11-05 | E-GEOD-25252 | biostudies-arrayexpress
GenomicsThe Menin–Bach2 axis is critical for regulating CD4 T cell senescence and homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanisms remain unclear. We found that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, accompanied by the senescence-associated secretory phenotype (SASP) after antigenic stimulati...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-53831 | biostudies-arrayexpress
TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
ProteomicsAn Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understanding of electrophile-sensitive cysteines in the human imm...
ORGANISM(S): Homo sapiens (Human) 
2024-02-12 | PXD049322 | Pride
Cysteine Activity-based protein profiling Birc3 Chemical proteomics Covalent electrophiles Protein degradation Human t cells Itk 
TranscriptomicsAcyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development
Gene expression profiling in non tumor lesion in the liver of patients prior to administering peretinoin was unrelated to the clinical outcome, however, gene expression profiling 8 weeks after starting peretinoin therapy significantly predicted the recurrence of HCC Peretinoin, a member of the acycl...
ORGANISM(S): Homo sapiens 
2012-08-19 | E-GEOD-29302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4-positive cells purified from peripheral blood of ATL patients
CD4-positive cells purified from peripheral blood of ATL patients.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-1466 | biostudies-arrayexpress
UnknownT cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.
Not available
S-EPMC7382475 | biostudies-literature
UnknownDevelopment of T cell receptor-engineered T cells targeting the sarcoma-associated antigen papillomavirus binding factor.
Not available
S-EPMC10823292 | biostudies-literature
UnknownT-cell counts in peripheral blood at leukapheresis predict responses to subsequent CAR-T cell therapy.
Not available
S-EPMC9636390 | biostudies-literature
UnknownThe significance of T-BET-positive CD8 T-cells with diminished CD5 expression in Kikuchi-Fujimoto disease.
Not available
S-EPMC11528254 | biostudies-literature
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