Sort   by:  
 Page size 
TranscriptomicsRole of IL-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) in mast cell response to lipopolysaccharide (LPS)
Mast cells are indispensable for LPS-induced septic hypothermia, in which TNF-α plays an essential role to initiate sepsis. Tec family non-receptor tyrosine kinases ITK and BTK regulate mast cell-derived TNF-α in response to allergic antigen, but their role in LPS-induced TNF-α production by mast...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-64287 | biostudies-arrayexpress
GenomicsTranscriptional analysis of noncanonical and canonical Tregs from ITK deficient mice (ITK KO)
Transcriptional analysis of noncanonical and canonical Tregs from ITK deficient mice (ITK KO)
PRJNA768766 | ENA
ProteomicsITK Degradation to Block T-cell Receptor Signaling and Overcome Therapeutic Resistance in T-Cell Lymphomas
IL-2-inducible T cell kinase (ITK) is essential for T cell receptor (TCR) signaling and plays an integral role in T-cell proliferation and differentiation. Unlike the ITK homolog BTK, no inhibitors of ITK are currently FDA approved. In addition, recent studies have identified mutations within BTK th...
ORGANISM(S): Homo sapiens (Human) 
2023-05-29 | PXD040668 | Pride
Lymphoma Cereblon Kinase Protac Ubiquitin Degrader Itk 
GenomicsITK-SYK induced peripheral T-cell lymphomas induce granulocyte activation
ITK-SYK induced peripheral T-cell lymphomas induce granulocyte activation
PRJNA917510 | ENA
TranscriptomicsDistinguishing innate memory CD8+ T from homeostatically expanded CD8+ T cells
Innate memory phenotype (IMP) CD8+ T cells are non-conventional αβ T cells exhibiting features of innate immune cells, and are significantly increased in the absence of non-receptor tyrosine kinase ITK. Their developmental path and function are not clear, particularly whether they can contribute to ...
ORGANISM(S): Mus musculus 
2013-02-19 | E-GEOD-41482 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of noncanonical and canonical Tregs from ITK deficient mice (ITK KO)
Regulatory T cells (Tregs) play a critical role in controlling autoimmunity and limiting tissue destruction and inflammation. IL2-inducible T cell kinase (Itk) belongs to the Tec family of tyrosine kinases and is an important component of TCR-mediated signaling. Here we showed that either genetic ab...
ORGANISM(S): Mus musculus 
2021-10-19 | GSE185327 | GEO
GenomicsThe Tec family kinase Itk is not required for Th17 responses during Hypersensitivity pneumonitis
The Tec family kinase Itk is not required for Th17 responses during Hypersensitivity pneumonitis
PRJNA695519 | ENA
TranscriptomicsTranscriptional signatures of Itk-deficiency using CD3+ T-cells
The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventional versus innate-like T-cell development. We have characterized the transcriptome of Itk-deficient CD3+ T-cells, including CD4+ and CD8+ subsets, using Affymetrix microarrays. The lar...
ORGANISM(S): Mus musculus 
2009-05-20 | GSE12464 | GEO
TranscriptomicsITK-SYK induced peripheral T-cell lymphomas induce granulocyte activation
ITK-SYK or control vector were overexpressed in Balb/c mice and ITK-SYK mice developed peripheral T-cell lymphomas within 5 weeks. CD4+ T-cells and granulocytes were harvested from the spleens of control and ITK-SYK mice and compared.
ORGANISM(S): Mus musculus 
2025-01-10 | GSE222050 | GEO
TranscriptomicsTranscription profiling of mouse Itk-deficiency using CD3+ T-cells
The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventional versus innate-like T-cell development. We have characterized the transcriptome of Itk-deficient CD3+ T-cells, including CD4+ and CD8+ subsets, using Affymetrix microarrays. The lar...
ORGANISM(S): Mus musculus 
2009-05-29 | E-GEOD-12464 | biostudies-arrayexpress
Sort   by:  
 Page size