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TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
ProteomicsPeriodontal pathogen induces entero-hepatic metabolic derangements in type 2 diabetic mouse model
This is the first report of the metabolic and metaproteomic integrated changes in the gut and liver by the swallowed periodontopathogen. Periodontal disease pathogen Porphyromonas gingivalis are observed in faeces as peptides level in proteomic analysis and make changes in bowel microbial compositio...
ORGANISM(S): Cellular Organisms 
2021-09-21 | PXD021851 | JPOST Repository
ProteomicsChronic high glucose condition reduced expressions of intercellular adhesion molecules and increased intercellular hyperpermeability in periodontal epithelium.
There is a close relationship between hyperglycemia in diabetes and progression of periodontal disease. This study aims to investigate the effect of hyperglycemia on the barrier function of gingival epithelial cells as a cause of hyperglycemia-exacerbated periodontitis in diabetes mellitus. Abnormal...
ORGANISM(S): Mus Musculus (mouse) 
2023-07-29 | PXD035613 | JPOST Repository
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