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MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 37,982 cells from diabetic...
2026-03-30 | MTBLS14184 | MetaboLights
UnknownMolecular cloning and analysis of the tryptophan oxygenase gene in the silkworm, Bombyx mori.
Not available
S-EPMC3062493 | biostudies-literature
ProteomicsRat heterotopic ossification model proteome
The mechanism of heterotopic ossification remains largely unclarified. in this project, we administrated Achilles tenotomy (AT) and partial Achilles tenotomy (PAT) to rat models to simulate the varied size of ectopic bone we observed in the clinical courses. Then we applied Data-independent acquisit...
ORGANISM(S): Rattus Norvegicus 
2021-04-28 | PXD025678 |
ProteomicsTMT-labeled quantitative proteomic reveals the effect of age on subcutaneous fat proteome of Chinese indigenous Ningxiang pig
Adipose tissue not only affects meat quality and animal productivity, but also participates in inflammation and immunity. Ningxiang pig is famous for their excellent meat quality, disease resistance and roughage-resistance. However, it is not yet clear how adipose tissue is dynamically regulated dur...
ORGANISM(S): Sus Scrofa Domesticus 
2021-12-18 | PXD030513 |
GenomicsRas-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model (RRBS-Seq]
Ras-related associated with diabetes (RRAD) is a small Ras-related GTPase that is frequently inactivated by DNA methylation of the CpG island in its promoter region in cancer tissues. However, the role of the methylation-induced RRAD inactivation in tumorigenesis remains unclear. In this study, the ...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-55566 | biostudies-arrayexpress
TranscriptomicsRas-induced epigenetic inactivation of RRAD promotes glucose uptake in a human ovarian cancer model [DGE-Seq]
Ras-related associated with diabetes (RRAD) is a small Ras-related GTPase that is frequently inactivated by DNA methylation of the CpG island in its promoter region in cancer tissues. However, the role of the methylation-induced RRAD inactivation in tumorigenesis remains unclear. In this study, the ...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-55567 | biostudies-arrayexpress
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
ProteomicsMuscular lactate modulates phase transition-driven lactate body secretion to induce liver fibrosis during long-term overtraining
Exercise, as the fundamental therapy for metabolic diseases, often exhibits a dose-dependent fashion. However, the adverse effects of overtraining and underlying mechanisms remain unclear. Here, we show that long-term overtraining induces hepatic fibrosis in humans and mice. Mechanistically, excessi...
ORGANISM(S): Mus Musculus 
2024-05-21 | PXD052424 |
UnknownEfficacy, safety and immunogenicity of a recombinant human papillomavirus bivalent (types 16, 18) vaccine in healthy 18-30-year-old Chinese women: a phase III, double-blind, randomized, controlled trial.
Not available
S-EPMC12870096 | biostudies-literature
ProteomicsIdentification of discriminative plasma protein biomarkers for recent Mycobacterium tuberculosis infection
This project presents a data-independent acquisition mass spectrometry (DIA-MS)–based plasma proteomics dataset generated to identify protein biomarkers associated with recent Mycobacterium tuberculosis (M.tb) infection. The study aimed to characterize proteomic differences among individuals with r...
ORGANISM(S): Homo Sapiens 
2026-02-09 | PXD074267 |
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