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TranscriptomicsGonadal transcriptome analysis in sterile double haploid Japanese flounder
We used the Illumina sequencing platform to analyze the transcriptome of sterile female DH Japanese flounder in order to identify major genes that cause sterility and to provide a molecular basis for an intensive study of gonadal development in teleosts. Through sequencing, assembly, and annotation,...
ORGANISM(S): Paralichthys olivaceus 
2015-12-10 | E-GEOD-75895 | biostudies-arrayexpress
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
TranscriptomicsAberrantly expressed lncRNAs in Primary Varicose Great Saphenous Veins
LncRNAs are key regulatory molecules involved in a variety of biological process and human diseases. However, the pathological effects of lncRNAs on primary varicose great saphenous veins (GSVs) remain unclear. In this study, we aimed at identifying aberrantly expressed lncRNAs involved in the preva...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51260 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cells engrafted into fetal goats
Robust human-goat chimerism was achieved by transplanting human CD34+Lin- cord blood cells into fetal goats. We observed a broad distribution of GFP-marked human cells in non-hematopoietic organs including kidney, muscle, lung, and heart of transplant goats. Various marker techniques indicated that...
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1801 | biostudies-arrayexpress
ProteomicsSDMA-shotgun analysis in pancreatic cancer cell lines
As a classic tumor suppressor pathway, Hippo signaling axis is activated by various extra-pathway factors to regulate cell differentiation and organ development. However, recent studies have reported that the activation of Hippo signaling pathway may be more dependent on the autophosphorylation of i...
ORGANISM(S): Homo Sapiens 
2023-08-18 | PXD044671 |
ProteomicsProteomic and transcriptomic analysis of Allium mongolicum seeds
Seeds, as an effective depository of plant genetic resources and an important raw material for germplasm innovation, aging or deterioration will directly lead to a reduction in germination rate, vigor and viability, inhibit the normal development of the seed embryo and seedling growth. Methods: Alli...
ORGANISM(S): Allium Mongolicum 
2024-11-18 | PXD058020 |
ProteomicsProteomic Profiling Reveals Indicative Biomarkers for Diabetic Retinopathy with Diabetic Kidney Disease
Diabetes retinopathy (DR) and diabetes kidney disease (DKD) are the complications of diabetes and causing serious health and economic burden to society. However, identification and characterization of early biomarkers for DKD, especially for non-proliferative DR (NPDR) patients with DKD, are still l...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036172 |
ProteomicsIntegrative proteomic and phosphoproteomic analyses reveal complex mechanisms of reproductive diapause in Bombus terretris queens (proteome)
Reproductive diapause is the overwintering strategy for Bombus terrestris, which is an important pollinator for agricultural production. However, the precise mechanisms of the reproductive diapause in bumble bees remain largely unclear. Here, a combination analyses of proteomics and phosphoproteomic...
ORGANISM(S): Bombus Terrestris 
2022-05-28 | PXD034198 |
ProteomicsIntegrative proteomic and phosphoproteomic analyses reveal complex mechanisms of reproductive diapause in Bombus terretris queens (phosphoproteome)
Reproductive diapause is the overwintering strategy for Bombus terrestris, which is an important pollinator for agricultural production. However, the precise mechanisms of the reproductive diapause in bumble bees remain largely unclear. Here, a combination analyses of proteomics and phosphoproteomic...
ORGANISM(S): Bombus Terrestris 
2022-05-28 | PXD034199 |
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo Sapiens 
2025-10-09 | PXD069246 |
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