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UnknownMETTL3 Regulates the Inflammatory Response in CPB2 Toxin-Exposed IPEC-J2 Cells through the TLR2/NF-κB Signaling Pathway.
Not available
S-EPMC9781724 | biostudies-literature
ProteomicsTMT labeled Comparative Proteomic Analysis Reveals Active Immune Response during Clostridium perfringens type C Infected Piglet Diarrhea
We performed a TMT labeling-based quantitative spleen proteomic analysis of the control group (SC), tolerance group (SR) and susceptible group (SS) to identify the differentially expressed proteins (DEPs), and screened potential molecular markers of piglet spleen tissues in response to C. perfringen...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-05-20 | PXD030745 | Pride
Tmt labeling  proteome  clostridium perfringens type c  piglet diarrhea  immune response  spleen 
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
UnknownADCY5 act as a putative tumor suppressor in glioblastoma: An integrated analysis.
Not available
S-EPMC11419897 | biostudies-literature
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
UnknownFTO Regulates Apoptosis in CPB2-Treated IPEC-J2 Cells by Targeting Caspase 3 Apoptotic Protein.
Not available
S-EPMC9264887 | biostudies-literature
UnknownRapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice.
Not available
S-EPMC4757870 | biostudies-literature
ProteomicsLactylation of Tau in Human Alzheimers Disease Brain
Aggregation of phosphorylated tau is associated with cognitive impairment in Alzheimers disease patients. In AD a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post-translational modification on proteins that conjugates lactyl groups to lysin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095881 | MassIVE
ProteomicsCombine in silico target fishing, Comparative proteomics analysis and in vitro assays to identify antibacterial effects of a TCM (the leaves of Strobilanthes cusia Kuntze) against the Penicillin resistant Streptococcus pneumoniae
The anti-bacterial mechanism of the leaves of Strobilanthes cusia Kuntze against the Penicillin-resistant Streptococcus pneumoniae were analyzed by the comparative proteomics
ORGANISM(S): Streptococcus Pneumoniae 23f 
2022-12-18 | PXD038886 |
ProteomicsLC-MS/MS identification of BMAL1 interaction proteins
Advances in circadian research revealed an intricate relationship between aging and circadian rhythms. However, whether and how the circadian machinery contribute to stem cell aging, especially in primates, remains poorly understood. In this study, we investigated the role of BMAL1, the only non-red...
ORGANISM(S): Homo sapiens (Human) 
2022-03-18 | PXD030570 | Pride
Bmal1 aging 
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