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TranscriptomicsSessile serrated adenomas and conventional adenomas of the colon
Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated ...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. pneumonia early response to to THP-1 human macrophages
Transcriptional responses of an unencapsulated Streptococcus pneumoniae strain derived from TIGR4 to human macrophages THP-1 were investigated at the early stages of interactions (0.5 h, 1 h and 3h).
ORGANISM(S): Streptococcus pneumoniae 
2008-10-21 | E-FPMI-16 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptococcus pneumoniae TCS08 mutant (disrupted in rr08) compared to the parent wild type strain TIGR4
Transcriptional changes of an TCS08 mutant (disrupted in rr08) compared to the parent wild-type strain TIGR4 when both strains were cultured to early logarithmic growth phase in THY broth.
ORGANISM(S): Streptococcus pneumoniae 
2008-12-20 | E-FPMI-17 | biostudies-arrayexpress
TranscriptomicsBrain endothelium gene expression during group B streptococcus (GBS) infection
The aim of this study was to investigate the response of human brain endothelial cells to bacterial (group B streptococcus, GBS) infection. Results: GBS WT strain infection results in a specific gene induction pattern that is different from the pilA mutant, but not other mutants such as pilB and srr...
ORGANISM(S): Homo sapiens 
2011-09-06 | E-MTAB-765 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes and Childhood Asthma in the Inner City [gene expression]
Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergi...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-40732 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes and Childhood Asthma in the Inner City [methylation]
Background: Epigenetic marks, like asthma, are heritable. They are influenced by the environment, direct the maturation of T cellslymphocytes, and have been shown to enhance the development of allergic airways disease in mice. Thus, we hypothesized that epigenetic marks are associated with allergi...
ORGANISM(S): Homo sapiens 
2015-02-02 | E-GEOD-40576 | biostudies-arrayexpress
GenomicsMassive Genomic Rearrangment Acquired in a Single Catastrophic Event During Cancer Development
Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatic...
EGAS00000000029 | EGA
UnknownA noncoding RNA modulator potentiates phenylalanine metabolism in mice.
Not available
S-EPMC9714245 | biostudies-literature
TranscriptomicsWhole blood expression profiling from a general population (KORA F4)
The development of whole genome association studies from the general population has lead to the robust identification of several loci involved in different common human diseases. Interestingly, most of the strongest signals of association observed in these studies arise from non-coding regions, rais...
ORGANISM(S): Homo sapiens 
2013-07-13 | E-MTAB-1708 | biostudies-arrayexpress
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
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