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MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
ProteomicsMS Analysis Reveals the Potential Signaling Pathway for RFWD2 Function in multiple myeloma
MS was conducted to assess activation of RFWD2-related signaling pathways.
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024507 |
UnknownTumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury.
Not available
S-EPMC12462958 | biostudies-literature
ProteomicsSFXN2 adjusts cell proliferation in multiple myeloma
SFXN2 adjusts cell proliferation in multiple myeloma
ORGANISM(S): Homo Sapiens 
PXD027607 |
ProteomicsCD229 promotes multiple myeloma cell proliferation by regulating RAS/ERK pathway
Flag antibody was used for immunoprecipitation, and cd229-OE partial binding protein was searched by protein spectrum in CD229-OE multiple myeloma cell line, and its interaction was analyzed.
ORGANISM(S): Homo Sapiens 
2022-03-09 | PXD032177 |
ProteomicsProteomics analysis of the myocardium form chronic hypobaric hypoxia-induced mice model
C57BL/6J mice were assigned to the hypobaric hypoxia chamber for simulation of high-altitude conditions. iTRAQ proteomics analysis/nanoUHPLC-MS/MS analysis was performed accordingly in the right myocardium of mice that had been allowed to develop hypoxia-induced pulmonary hypertension after hypobari...
ORGANISM(S): Mus Sp. 
2023-02-23 | PXD040342 |
TranscriptomicsGlobal expression profile difference of hiPSCs between hESCs and human Urine-Derived Cells
Compare difference Global expression profile of hiPSCs between hESCs and human Somatic cells, showing that hiPSCs and hESCs is consistent in lineages and indicated that the induce method is safe and reliable. There are three groups of samples, each group has two repeated samples, hiPSCs respectively...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-85885 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human papillary renal cell carcinoma to identify molecular PRCC subclasses with morphologic correlation
BACKGROUND: Despite the moderate incidence of papillary renal cell carcinoma; (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphological ...
ORGANISM(S): Homo sapiens 
2007-10-20 | E-GEOD-2748 | biostudies-arrayexpress
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