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TranscriptomicsExpression Data from HNF4a RNAi Knockdown in HepG2 cells
HNF4a is an important liver transcription factor that regulates at least a thousand genes in the liver. Here we used expression profiling in HepG2 cells, a hepatocellular carcinoma cell line, in which HNF4a was knocked down by RNAi to identify some of those target genes. This dataset accompanies the...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-29084 | biostudies-arrayexpress
UnknownAssociation Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults: A Systematic Review and Meta-analysis.
Not available
S-EPMC5656237 | biostudies-literature
TranscriptomicsHairpin Capture of DNA End Structures reveals chromosomal DNA end structure with single nucleotide resolution
The structure of broken DNA ends is a critical determinant of the pathway used for DNA double strand break (DSB) repair. Here, we develop an approach, hairpin capture of DNA end structures (HCoDES), which elucidates chromosomal DNA end structures at single nucleotide resolution. HCoDES defines str...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62534 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ModelsFisher2006_NFAT_Activation
The model reproduces the kinetics of the nuclear factor of activated cells (NFAT) as depicted in Figure 3a of the paper. Model was successfully tested on Jarnac and MathSBML To the extent possible under law, all copyright and related or neighbouring rights to this encoded mo...
2024-09-02 | BIOMD0000000123 | BioModels
ModelsFisher2006_Ca_Oscillation_dpdnt_NFAT_dynamics
The model reproduces the calcium oscillation dependent activation-deactivation kinetics of nuclear factor of activated T cells (NFAT) as depicted in Fig 4a of the paper. A simple algorithm in the events section takes care of the calcium oscillation. The model was successfully tested on MathSBML. ...
2024-09-02 | BIOMD0000000122 | BioModels
TranscriptomicsExpression data from MTDH knockdown in the Hec50co endometrial cancer cell line
Understanding the molecular underpinnings of chemoresistance is vital to design therapies to restore chemosensitivity. In particular, metadherin (MTDH) has been demonstrated to have a critical role in chemoresistance. Over-expression of MTDH has recently been implicated in poor clinical outcome in b...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-26134 | biostudies-arrayexpress
UnknownA real-world study to assess the association of cardiovascular adverse events (CVAEs) with ibrutinib as first-line (1L) treatment for patients with chronic lymphocytic leukaemia (CLL) in the United States.
Not available
S-EPMC9928661 | biostudies-literature
UnknownA genetic screen for temperature-sensitive morphogenesis-defective Caenorhabditis elegans mutants.
Not available
S-EPMC8133775 | biostudies-literature
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
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