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ProteomicsPUMILIO Proteins in Colorectal Cancer: Tumor Growth Promoting Function and Potential as Therapeutic Targets
We employ Mass spectrum to investigate proteome of Pum1-Knockout, Pum2-Knockout and WT conditions in human colorectal cancer cell line Hct116. Overall design: In order to investigate whether Pum1 and Pum2 regulate their targets at their protein levels, we used Pum1-Knockout, Pum2-Knockout and WT Hct...
ORGANISM(S): Homo Sapiens 
2021-07-23 | PXD027513 |
ProteomicsLongitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19
This study presents a longitudinal multi-omics analysis of COVID-19 convalescents with respiratory sequelae, spanning 6–36 months post-infection. The integrating proteomic and metabolomic profiling uncovers persistent molecular alterations, impaired diffusing capacity for carbon monoxide, and propos...
ORGANISM(S): Homo Sapiens 
2025-02-23 | PXD061113 |
ProteomicsA chaperone-like function of FUS ensures TAZ condensates dynamics and transcriptional activation
The Hippo pathway plays important roles in organ development, tissue homeostasis, and tumor growth, and its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the formation of biomolecular condensates. However, the mechanisms that regulate the biop...
ORGANISM(S): Homo Sapiens 
2023-02-17 | PXD040257 |
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