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ProteomicsSirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis
Proximal tubular epithelial cells (TECs) demand high energy and rely on mitochondrial oxidative phosphorylation as a main energy source. However, this is disturbed in renal fibrosis. Acetylation is an important posttranslational modification for mitochondrial metabolism. The mitochondrial protein NA...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD021357 | Pride
Mouse Kidney Tubules Lc-ms/ms 
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
ProteomicsMAP2K6 Directly Phosphorylates BCL2L13 to Mediate Mitophagy for Suppressing Tumorigenicity
Raw MS data of proteomic or phosphoproteomic in A549 cells
ORGANISM(S): Homo Sapiens 
2026-02-26 | PXD074976 |
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