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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
TranscriptomicsGene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model
The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 gene...
ORGANISM(S): Mus musculus 
2009-04-14 | E-GEOD-14449 | biostudies-arrayexpress
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
TranscriptomicsGenome-wide analysis of tumor regression upon K-RAS inactivation
We performed expression profiling on micro-dissected lung tumors derived from a doxycycline-inducible K-RAS mouse model in order to gain mechanistic insight into K-RAS-mediated tumor maintenance. In this model, the tumors were induced with doxycycline for 11 weeks (in order to obtain lung tumors). A...
ORGANISM(S): Mus musculus 
2012-09-06 | E-GEOD-40606 | biostudies-arrayexpress
ProteomicsSite-Link for identification of chromatinized proteome defined by site-specific histone acylations in living cells
By coupling the mass spectrometry, we developed the Site-Link strategy based on the GCE method for analyzing the interacting proteome of histone lysine acylations in living cells. As K* could mimic the natural lysine to be recognized by natural lysine synthase, histones bearing the site-specifically...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD033959 | Pride
K*56pabk* Site-link K*37cr K*56ac 
TranscriptomicsGene expression in epithelial and non-epithelial cells of renal origin
We aimed to define epithelial-specific genes in the kidney. In the developing mouse kidney at E12.5 epithelial cells are restricted to the ureteric bud, while mesenchymal cells surrounding the ureteric bud are non-epithelial. The mouse renal epithelial cell line mIMCD-3 was used to represent kidney ...
ORGANISM(S): Mus musculus 
2010-09-23 | E-GEOD-24295 | biostudies-arrayexpress
UnknownMRI Safety Considerations for Permanent Magnet Implants in Muscle.
Not available
S-EPMC12810996 | biostudies-literature
TranscriptomicsMEF-mKras-WT1
K-ras is one of the most frequently mutated human oncogenes. Activation of K-ras can lead to either senescence or proliferation in primary cells. The precise mechanism governing these distinct outcomes remains unclear. Here we utilized a loss-of-function screen to assess the role of specific genes ...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-15325 | biostudies-arrayexpress
ProteomicsYang: Site-specific mapping and quantification of protein S-sulfenylation in cells
The files in this archive represent the supporting data for "Site-specific mapping and quantification of protein S-sulfenylation in cells," a paper to appear in Nature Communications (2014). The authors are Jing Yang, Vinayak Gupta, Kate S. Carroll, and Daniel C. Liebler, working at Vanderbilt Univ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-07-10 | MSV000078777 | MassIVE
TranscriptomicsTranscription profiling of E. coli K-12 wild type with R1drd19 biofilm vs wild type without R1drd19 biofilm
E. coli K-12 wild type strains gene expression in biofilm cells with R1drd19 relative to that in biofilm cells of E. coli K-12 wild type strains without R1drd19. All the samples were cultured in LB or M9C glu on glass wool at different time. Experiment Overall Design: Strains: E. coli K-12 strains ...
ORGANISM(S): Escherichia coli 
2008-04-05 | E-GEOD-6923 | biostudies-arrayexpress
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