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UnknownAssociations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.

Background and objective

Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.

Methods

Based on...
S-EPMC7617645 | biostudies-literature
UnknownSpirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers.

Background

Existing studies have not provided robust evidence about the CVD risk of non-smoking patients with restrictive spirometric pattern (RSP) or airflow obstruction (AFO), and how the risk is modified by body shape. We aimed to bridge the gap.

Methods

We used never-smokers' data...
S-EPMC11750506 | biostudies-literature
UnknownPredictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years.

Aims

The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well as their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multiple BP measures with subsequent 5-year ICH risk, as we...
S-EPMC7616516 | biostudies-literature
UnknownConventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited.

Background

Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations with mortality, particularly at lower BMI levels.

Methods

The prospective China Kadoo...
S-EPMC11464668 | biostudies-literature
UnknownCerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Background

Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that o...
S-EPMC6562236 | biostudies-literature
UnknownGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observ...
S-EPMC3969612 | biostudies-literature
UnknownPolygenic prediction of body mass index and obesity through the life course and across ancestries.
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the ...
S-EPMC12443623 | biostudies-literature
UnknownCorrection : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies.
Not available
S-EPMC10214330 | biostudies-literature
UnknownVariability of oxygen requirements in critically ill COVID-19 patients.

Background

The global scarcity of medical oxygen has proven to be catastrophic during the surges in COVID-19 cases over the past two years, with the heaviest burden felt in low- and middle-income countries. Despite its criticality, data and analyses of oxygen consumption, even for typical cl...
S-EPMC10884784 | biostudies-literature
UnknownEarly short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis.

Background

The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-...
S-EPMC9112652 | biostudies-literature
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