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ProteomicsMetabolic bypass partially rescues S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons
In Alzheimer’s disease (AD), dysfunctional mitochondrial metabolism has been associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild-type and AD mutant human induced plur...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042436 | Pride
S-nitrosylation Alzheimer’s disease Mitochondrial metabolism Tca cycle inhibition 
TranscriptomicsSessile serrated adenomas and conventional adenomas of the colon
Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated ...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12514 | biostudies-arrayexpress
UnknownA miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells.
Not available
S-EPMC8129150 | biostudies-literature
TranscriptomicsTranscription profiling of mouse aorta and vSMCs response to dioxin
We compared the global gene expression profiles of C57BL/6 mice aortas with the profiles of cultured vascular smooth muscle cells (vSMC) from the same mice, and determined whether gene responses to dioxin exposure in the vSMCs would be predictive of responses in the aorta.
ORGANISM(S): Mus musculus 
2003-10-29 | E-MEXP-23 | biostudies-arrayexpress
UnknownAnti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression.
Not available
S-EPMC6648346 | biostudies-literature
TranscriptomicsProgrammed fluctuations in sense/anti-sense transcript ratios drive sexual differentiation in Schizosaccharomyces pombe
Strand specific RNA sequencing of S. pombe revealed a highly structured programme of ncRNA expression at over 600 loci. Waves of antisense transcription accompanied sexual differentiation. A substantial proportion of ncRNA arose from mechanisms previously considered to be largely artefactual, includ...
ORGANISM(S): Schizosaccharomyces pombe 
2011-12-20 | E-GEOD-28113 | biostudies-arrayexpress
GenomicForegut Microbiome in Development of Esophageal Adenocarcinoma

The distal esophagus is an important anatomical area where gastric acid reflux can cause reflux esophagitis (RE), Barrett's esophagus (BE) (intestinal metaplasia), and esophageal adenocarcinoma (EA). The incidence of EA has increased 6-fold in the U.S. since the 1970s, parallel to a significa...

phs000260 | dbGaP
TranscriptomicsTranscription profiling of human CD4+/CD8+ T cells obtained from HIV patients at various stages of disease vs. uninfected individuals reveals HIV infection induces a persistent T cell transcriptional profile
We examined the gene expression profiles in ex vivo human CD4+ and CD8+ T cells from untreated HIV-infected individuals at different clinical stages and rates of disease progression. Profiles of pure CD4+ and CD8+ T cells subsets from HIV-infected nonprogressors who controlled viremia were indisting...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-6740 | biostudies-arrayexpress
TranscriptomicsSmall molecule activation of PKM in cancer cells induces serine auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM isoform, effectively constraining lower glycolysis. Here, we report the discovery of novel PKM activators with ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-40191 | biostudies-arrayexpress
UnknownUnusual conservation among genes encoding small secreted salivary gland proteins from a gall midge.
Not available
S-EPMC2955719 | biostudies-literature
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