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UnknownInherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.
Not available
S-EPMC4375304 | biostudies-literature
UnknownShort-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.
Not available
S-EPMC5956241 | biostudies-literature
TranscriptomicsGenes downstream of p53 mediating its effect on megakaryopoiesis
In order to examine genes whose expression is altered as a result of the knock-down (KD) of p53, we used gene expression microarray analysis based on the CHRF cell line, a human megakaryoblastic cell line, which upon PMA stimulation undergoes polyploidization, and extends proplatelet-like cytoplasmi...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-30984 | biostudies-arrayexpress
ProteomicsTriple SILAC exosomal quantitative proteomic analysis
Exosomes are 30-100 nm sized membrane vesicles released by cells into extracellular space and mediate the intercellular communication via transfer of proteins and RNAs. To better understand the function of these microvesicles in lung carcinogenesis, we employed a Triple SILAC quantitative proteomic ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-02 | MSV000079882 | MassIVE
MetabolomicsGNPS - Molecular networking as a dereplication strategy -Figure 4
Molecular networking as a dereplication strategy. Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC. J Nat Prod. 2013 Sep 27;76(9):1686-99. doi: 10.1021/np400413s PubMedID: 240...
ORGANISM(S): Data From Multiple Bacteria 
2014-02-11 | MSV000078547 | GNPS
MetabolomicsGNPS - Molecular networking as a dereplication strategy-Figure 3
Molecular networking as a dereplication strategy. Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, Dorrestein PC. J Nat Prod. 2013 Sep 27;76(9):1686-99. doi: 10.1021/np400413s PubMedID: 24...
ORGANISM(S): Six Distinct Collections Of Cyanobacteria 
2014-02-11 | MSV000078548 | GNPS
UnknownTP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.
Not available
S-EPMC5815403 | biostudies-literature
TranscriptomicsTranscription profiling of human leukemia cells treated with mercaptopurine and/or methotrexate
To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-412 | biostudies-arrayexpress
UnknownClinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.
Not available
S-EPMC4962704 | biostudies-literature
TranscriptomicsTranscription profiling of human drug sensitive and resistant ALL cells obtained at diagnosis from 174 patients
Cellular drug resistance is associated with an unfavorable prognosis in pediatric acute lymphoblastic leukemia (ALL). To identify genes conferring resistance to antileukemic agents, we analyzed the expression of >12,700 genes in sensitive and resistant ALL cells obtained at diagnosis from 174 patien...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-635 | biostudies-arrayexpress
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