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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
ProteomicsSUMOylation-Induced Membrane Localization of TRPV1 Suppresses Proliferation and Migration in Gastric Cancer Cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050942 |
ProteomicsThe role and mechanism of TRPV1 SUMOylation in inhibiting the proliferation and migration of gastric cancer cells
In this work, we elucidate a novel mechanism wherein TRPV1 SUMOylation promotes its membrane expression and activates the TRPV1-Ca2+-AMPK signaling pathway, thereby inhibiting GC cell proliferation and migration. These findings enhance our understanding of the molecular dynamics in gastric cancer an...
ORGANISM(S): Mus Musculus 
2024-03-25 | PXD050941 |
ProteomicshnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain
We show here that the up-regulation of SUMO1-conjugated protein levels in a CFA-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels.
ORGANISM(S): Homo Sapiens 
PXD046199 |
ProteomicsDIA proteomics analysis of mice in models of myocardial infarction and heart failure with preserved ejection fraction (HFpEF).
The dataset includes two parts: a) Proteomics of mouse heart tissue 14 days after myocardial infarction and long-term exercised mice post-myocardial infarction for 14 days; b) Cardiac proteomics of a model of heart failure with preserved ejection fraction (HFpEF) induced by L-NAME and high-fat diet-...
ORGANISM(S): Mus Musculus 
PXD051242 |
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