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ProteomicsTetramethylpyrazine improves cognitive impairment and modifies the hippocampal proteome in two mouse models of Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. So far, there is no effective treatment for this condition. Tetramethylpyrazine (TMP) is an alkaloid extracted from traditional Chinese medicine chuanxiong, which is mainly used in the treatment of ischemic stroke some re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022840 | Pride
Tetramethylpyrazine  alzheimer’s disease (ad)  proteomics  mitochondria  oxphos 
ProteomicsTetramethylpyrazine improves cognitive impairment and modifies the hippocampal proteome in two mouse models of Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. So far, there is no effective treatment for this condition. Tetramethylpyrazine (TMP) is an alkaloid extracted from traditional Chinese medicine chuanxiong, which is mainly used in the treatment of ischemic stroke some re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022862 | Pride
Tetramethylpyrazine  alzheimer’s disease (ad)  proteomics  mitochondria  oxphos 
ProteomicsLow-dose Copper exposure exacerbates depression-like behavior in ApoE4 transgenic mice
Depression is one of the most common neuropsychiatric disorders. Although the pathogenesis of depression is still unknown, environmental risk factors and genetics are implicated. Copper (Cu), a cofactor of multiple enzymes, is involved in regulating depression-related processes. Depressed patients c...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022422 | Pride
Depression  proteomics  copper (cu)  apoe4 
TranscriptomicsEndothelial C/EBPβ/AEP Pathway Drives Vascular Deterioration and Systemic Aging
Age-related microvascular dysfunction disrupts nutrient homeostasis and waste clearance, leading to organ failure. However, a critical gap remains in our understanding of the specific molecular drivers of vascular deterioration and how they orchestrate organism-wide aging. Here, we identify progress...
ORGANISM(S): Mus musculus 
2026-05-30 | E-MTAB-17006 | biostudies-arrayexpress
ProteomicsA classic famous prescription alleviates inflammation in CUMS model mice via modulating MYDGF/MAP4K4/NF-κB signaling pathway, verified through UPLC-HRMS and proteomics analysis
Major depressive disorder (MDD) has caused a heavy burden on society and affected over 350 million patients worldwide currently. However, there have been 30-50% MDD patients with non-response to antidepressants. Chronic unpredictable mild stress (CUMS) has been considered as a critical trigger facto...
ORGANISM(S): Mus Sp. 
PXD053391 |
ProteomicsMass spectrum data for the manuscript "Mitochondriomics reveals the underlying neuoprotective mechanism of TrkB receptor agonist R13 in the 5xFAD mice"
This is the original mass spectrometry data, which includes 45 mass spectra data and a search database table. All these data and sample processing methods can refer to the ca in the manuscript
ORGANISM(S): Mus Musculus 
2021-02-19 | PXD024268 |
ProteomicsMulti-omics analysis of human peripheral blood reveals marked molecular profiling changes caused by one night of sleep deprivation
Sleep insufficiency is associated with various disorders (cardiovascular disease, neurodegenerative diseases, immunological disorders.) but the molecular bases for these associations are largely unknown. We used multiple omics techniques to examine changes in the blood of healthy male and female adu...
ORGANISM(S): Homo Sapiens 
PXD033402 |
ProteomicsCopper exposure aggravates motor phenotype via inhibiting mitophagy in SOD1G93A transgenic mice
Background Amyotrophic lateral sclerosis (ALS) is an age-dependent and incurable neurodegenerative disease. It is pathologically characterized by selective degeneration of motor neurons resulting in a catastrophic loss of motor function. Previous studies showed that excess copper (Cu) might have a r...
ORGANISM(S): Mus Musculus 
2023-01-29 | PXD039728 |
ProteomicsAcer truncatum seed oil alleviates learning and memory impairments of aging mice
Proteomics raw data for “Acer truncatum seed oil alleviates learning and memory impairments of aging mice”
ORGANISM(S): Mus Musculus 
2021-03-16 | PXD024948 |
ProteomicsDiscovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
ORGANISM(S): Mus Musculus 
PXD069462 |
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