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ProteomicsA Bifunctional SPD-0090 contributes virulence of Streptococcus pneumoniae by affecting iron transport and galactose metabolism
Streptococcus pneumoniae (S.pneumoniae) is a Gram-positive bacterial pathogen that colonizes on the mucosal surfaces of the host's nasopharynx and upper respiratory tract and results in pneumonia. In order to survive and infect the host, S.pneumoniae must have obtain essential nutrients, such as tra...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2022-06-01 | PXD030183 | Pride
Spd-0090 Virulence Iron transport protein Galactose metabolism Streptococcus pneumoniae 
MetabolomicsTranscriptomic and Metabolomics Profiling of Phage–Host Interactions between Phage PaP1 and Pseudomonas aeruginosa
The basic biology of bacteriophage–host interactions has attracted increasing attention due to a renewed interest in the therapeutic potential of bacteriophages. In addition, knowledge of the host pathways inhibited by phage may provide clues to novel drug targets. However, the effect of phage on ba...
2018-05-03 | MTBLS431 | MetaboLights
ProteomicsImproved SILAC Method for Double Labeling of Bacterial Proteome
Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with the advantages of reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quanti...
ORGANISM(S): Staphylococcus aureus 
2022-03-02 | PXD011221 | Pride
Proteomics Double labeling Bacteria Silac 
ProteomicsImproved SILAC Method for Double Labeling of Bacterial Proteome
Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with the advantages of reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quanti...
ORGANISM(S): Escherichia coli Staphylococcus aureus 
2022-02-28 | PXD011244 | Pride
Proteomics Double labeling Bacteria Silac 
ProteomicsQuantitative crotonylation proteomic analysis on Streptococcus pneumoniae
To further identify endogenous substrates of SPD_0839 and establish its regulatory network, quantitative proteomic analysis was performed on the spd_0839+ and p169 strains.
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-03-09 | PXD058867 | Pride
Crotonylation Lc-ms/ms Streptococcus pneumoniae 
ProteomicsiTRAQ-Based Proteomics Analysis Revealed Proteins Involved in Drought Response During the Germination Stage in Faba Bean
iTRAQ-Based Proteomics Analysis Revealed Proteins Involved in Drought Response During the Germination Stage in Faba Bean
ORGANISM(S): Vicia Faba 
2023-11-17 | PXD047083 |
ProteomicsDIA proteomics of preeclampsia placental tissues
Preeclampsia (PE) has become severe diseases that endangers the safety of mothers and fetuses worldwide.More studies on novel biomarkers for PE are inevitable. Data-independent acquisition proteomics, with five biological replicates, was used to investigate the protein expression profiles from place...
ORGANISM(S): Homo Sapiens 
2021-07-14 | PXD027276 |
ProteomicsAddressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as a NAD+ synthase and unexpectedly, an extrac...
ORGANISM(S): Homo Sapiens 
PXD028453 |
ProteomicsAddressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via two PROTAC-Mediated Degradation
The rate-limiting enzyme of salvage pathway for NAD+ synthesis, NAMPT, is aberrantly overexpressed in a variety of tumor cells and is a poor prognosis factor for patient survival. NAMPT plays a major role in tumor cell proliferation, acting concurrently as an NAD+ synthase and unexpectedly, an extra...
ORGANISM(S): Homo Sapiens 
2022-01-24 | PXD031185 |
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