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TranscriptomicsGene expression analysis of lentivirally-transduced rhesus macaque CD34+ cells long-term following transplant
The occurrence of clonal perturbations and leukemia in patients transplanted with retrovirally-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions perturb adjacent proto-oncogene expression. Although enh...
ORGANISM(S): Macaca mulatta 
2013-11-05 | E-GEOD-46032 | biostudies-arrayexpress
TranscriptomicsHeme-Bound Iron Activates Placenta Growth Factor via Erythroid KrM-CM-
We have tested the effect of iron on the gene expression profile in human leukemia cells with properties of erythroid differentiation. 12 Total samples were analyzed. We compared the gene expression profiles of cells treated with iron mesoporphyrin to mesoporphyrin alone. DMSO vehicle was also teste...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-52087 | biostudies-arrayexpress
TranscriptomicsExpression data from ARPE-19 cells treated with LDL or ox-LDL
LDL or Ox-LDL 200ug/ml, which showed no loss of viability after a 48 hour exposure, induced a physiological and pathological transcriptional response, respectively. LDL induced a downregulation of genes associated with cholesterol biosynthesis while ox-LDL induced transcriptional alterations in gene...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5741 | biostudies-arrayexpress
TranscriptomicsCharacterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.
Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with low RNA copy number including platelets. Resulting studies have used RNA-seq in platelets isolated from healthy individuals to characterize the platelet transcriptome. However, platelets, possibly throu...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-65705 | biostudies-arrayexpress
TranscriptomicsInducing pluripotency from mouse somatic cells by small-molecule compounds [RNA-Seq]
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource for regenerative medicine. However, genetic manipulation and difficult-to-manufacture strategies used in reprogramming limit their clinical applications. Here, we show pluripotency can be induced from mous...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-48252 | biostudies-arrayexpress
TranscriptomicsGeneration of murine stem cells by small molecule
Transcriptional profiling of stem cells and parental cells Two samples were analyzed: PEG cells and parental cells. Each sample have three replicates.
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-47102 | biostudies-arrayexpress
ProteomicsDiverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecu...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038754 |
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