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ProteomicsNafamostat Mesilate Improves Sepsis Outcomes by Modulating Complement and Coagulation Pathways
Supporting data for: Nafamostat Mesilate Improves Sepsis Outcomes by Modulating Complement and Coagulation Pathways
ORGANISM(S): Homo Sapiens 
2026-02-24 | PXD074871 |
ProteomicsSi-pgc-1 α LNP prevents bladder cancer metastasis by inhibiting mitochondrial biogenesis and energy metabolism in cancer cells
This study aims to explore the effect of PGC-1 α siRNA delivered by liposomal nanoparticles on cancer cells through transcriptome, proteome and metabolome technologies, so as to reveal its regulatory effect on cancer cell reprogramming and energy metabolism, so as to provide clues for the molecular ...
ORGANISM(S): Mus Musculus 
2025-03-22 | PXD062155 |
ProteomicsTargeting PGC-1α in Bladder Cancer: Unraveling Energy Metabolism Reprogramming for Therapeutic Intervention
Metastatic bladder cancer is a malignant tumor with high metastatic potential. The etiology and molecular mechanism are still not fully understood. This study aimed to investigate the effect of PGC-1 α siRNA delivered by liposomal nanoparticles on bladder cancer cells, in order to reveal its mechani...
ORGANISM(S): Mus Musculus 
2025-03-22 | PXD062153 |
ProteomicsEvaluation of the power of DeepRTAlign to eliminate missing values
Four samples were prepared: 293T digest (73%, 91%, 97% and 99%) offset by varied proportions (27%, 9%, 3% and 1%) of E.coli digest. 10 μg of 293T and E. coli mixtures were loaded each time and the DDA data were collected from six Orbitrap Exploris 480 mass spectrometers with the same settings.
ORGANISM(S): Homo Sapiens 
PXD046183 |
ProteomicsRT alignment test of DeepRTAlign using data under two gradients
Nano-flow LC-MS/MS analysis of 293T digest in two gradients.
ORGANISM(S): Homo Sapiens 
2023-08-01 | PXD044221 |
ProteomicsPerformance evaluation of DeepRTAlign using 293T-E.coli mixture datasets
10 μg 293T was spiked with different amounts ( 0.2, 0.3, 0.4, 0.5 μg) of E.coli. Performed the ablation analysis to evaluate the DNN model in DeepRTAlign. Compared DeepRTAlign with Quandenser. Compared DeepRTAlign with MaxQuant’s MBR and FragPipe’s MBR. Generalizability evaluation on simulated datas...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2023-07-31 | PXD044222 |
ProteomicsReliability test of the QC module in DeepRTAlign
Micro-flow LC-MS/MS analysis of pure 293T or E.coli.
ORGANISM(S): Homo Sapiens 
2023-07-31 | PXD044223 |
ProteomicsDeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis
PRM datasets and Skyline results for the validation of ion-centric findings.
ORGANISM(S): Homo Sapiens 
2023-07-31 | PXD044224 |
ProteomicsCAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
HIV-1 latency is a major obstacle to achieve a functional cure for AIDS. To eradicate the viral reservoir, one of the strategies is to specifically reactivate HIV-1-infected cells and followed by elimination with potent immune surveillance. However, present latency-reversing agents (LRAs) are quite ...
ORGANISM(S): Homo Sapiens 
2021-02-09 | PXD024172 |
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